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MedKoo Cat#: 471141 | Name: Rhamnocitrin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Rhamnocitrin is a flavonoid that has diverse biological activities and inhibits IL-6 mRNA expression. Rhamnocitrin was found to have binding affinity towards NDM-6, NDM-9, and NDM-23.

Chemical Structure

Rhamnocitrin
Rhamnocitrin
CAS#569-92-6

Theoretical Analysis

MedKoo Cat#: 471141

Name: Rhamnocitrin

CAS#: 569-92-6

Chemical Formula: C16H12O6

Exact Mass: 300.0630

Molecular Weight: 300.27

Elemental Analysis: C, 64.00; H, 4.03; O, 31.97

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 650.00 2 Weeks
25mg USD 1,250.00 2 Weeks
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Related CAS #
No Data
Synonym
Rhamnocitrin; C.I. 75650, Kaempferol 7-O-methyl ether; C.I-75650
IUPAC/Chemical Name
3,5-dihydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one
InChi Key
MQSZRBPYXNEFHF-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H12O6/c1-21-10-6-11(18)13-12(7-10)22-16(15(20)14(13)19)8-2-4-9(17)5-3-8/h2-7,17-18,20H,1H3
SMILES Code
O=C1C(O)=C(OC2=CC(OC)=CC(O)=C12)C3=CC=C(C=C3)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 300.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Du R, Xu F, Wei D, Wei Y, Wang Z, Wang Z. Pharmacokinetics of two triterpenoid saponins and three flavonoids in Astragalus membranaceus leaves by UHPLC-MS/MS. J Pharm Biomed Anal. 2024 Dec 15;251:116419. doi: 10.1016/j.jpba.2024.116419. Epub 2024 Aug 15. PMID: 39154580. 2: El-Ayouty MM, Eltahawy NA, Abd El-Sameaa AM, Badawy AM, Darwish KM, Elhady SS, Shokr MM, Ahmed SA. In vivo determination of analgesic and anti- inflammatory activities of isolated compounds from Cleome amblyocarpa and molecular modelling for the top active investigated compounds. RSC Adv. 2024 Aug 5;14(34):24503-24515. doi: 10.1039/d4ra04496g. PMID: 39108954; PMCID: PMC11299235. 3: Wang YL, Ni Q, Zeng WH, Feng H, Cai WF, Chen QC, Lin SX, Jiang CP, Yi YK, Shen Q, Shen CY. Antioxidant, Antimicrobial, and Anti-Inflammatory Effects of Liriodendron chinense Leaves. ACS Omega. 2024 Jun 10;9(25):27002-27016. doi: 10.1021/acsomega.3c10269. PMID: 38947843; PMCID: PMC11209703. 4: Zhu Y, Ouyang H, Lv Z, Yao G, Ge M, Cao X, Chang Y, He J. Simultaneous determination of multiple components in rat plasma by UPLC-MS/MS for pharmacokinetic studies after oral administration of Pogostemon cablin extract. Front Pharmacol. 2024 May 22;15:1293464. doi: 10.3389/fphar.2024.1293464. PMID: 38841366; PMCID: PMC11150675. 5: Bai X, Zhao X, Liu K, Yang X, He Q, Gao Y, Li W, Han W. Mulberry Leaf Compounds and Gut Microbiota in Alzheimer's Disease and Diabetes: A Study Using Network Pharmacology, Molecular Dynamics Simulation, and Cellular Assays. Int J Mol Sci. 2024 Apr 5;25(7):4062. doi: 10.3390/ijms25074062. PMID: 38612872; PMCID: PMC11012793. 6: Neog N, Puzari M, Chetia P. Identification of Potential Inhibitors of Three NDM Variants of Klebsiella Species from Natural Compounds: A Molecular Docking, Molecular Dynamics Simulation, and MM-PBSA Study. Curr Comput Aided Drug Des. 2024 Mar 18. doi: 10.2174/0115734099294294240311061115. Epub ahead of print. PMID: 38504567. 7: Yadava A, Bhuyan MMR, Mukherjee D, Kumar D, Dwivedi M. Phytomolecules as potential candidates to intervene the function of E. coli sodium-proton antiporters; Ec-NhaA. J Biomol Struct Dyn. 2023;41(24):15598-15609. doi: 10.1080/07391102.2023.2191130. Epub 2023 Mar 19. PMID: 36935099. 8: de Souza Silva AP, de Camargo AC, Lazarini JG, Franchin M, Sardi JCO, Rosalen PL, de Alencar SM. Phenolic Profile and the Antioxidant, Anti-Inflammatory, and Antimicrobial Properties of Açaí (Euterpe oleracea) Meal: A Prospective Study. Foods. 2022 Dec 24;12(1):86. doi: 10.3390/foods12010086. PMID: 36613302; PMCID: PMC9818655. 9: Zeng P, Liu YC, Wang XM, Ye CY, Sun YW, Su HF, Qiu SW, Li YN, Wang Y, Wang YC, Ma J, Li M, Tian Q. Targets and mechanisms of Alpinia oxyphylla Miquel fruits in treating neurodegenerative dementia. Front Aging Neurosci. 2022 Nov 30;14:1013891. doi: 10.3389/fnagi.2022.1013891. PMID: 36533181; PMCID: PMC9749063. 10: Park SW, Lee AY, Lim JO, Lee SJ, Kim WI, Yang YG, Kim B, Kim JS, Chae SW, Na K, Seo YS, Shin IS. Loranthus tanakae Franch. & Sav. Suppresses Inflammatory Response in Cigarette Smoke Condensate Exposed Bronchial Epithelial Cells and Mice. Antioxidants (Basel). 2022 Sep 23;11(10):1885. doi: 10.3390/antiox11101885. PMID: 36290608; PMCID: PMC9598098. 11: Zhou YY, He CH, Lan H, Dong ZW, Wu YQ, Song JL. Rhamnocitrin decreases fibrosis of ovarian granulosa cells by regulating the activation of the PPARγ/NF-κB/TGF-β1/Smad2/3 signaling pathway mediated by Wisp2. Ann Transl Med. 2022 Jul;10(14):789. doi: 10.21037/atm-22-2496. PMID: 35965823; PMCID: PMC9372664. 12: Punia Bangar S, Sharma N, Sanwal N, Lorenzo JM, Sahu JK. Bioactive potential of beetroot (Beta vulgaris). Food Res Int. 2022 Aug;158:111556. doi: 10.1016/j.foodres.2022.111556. Epub 2022 Jun 23. PMID: 35840248. 13: Patel DK. Biological Importance and Therapeutic Benefit of Rhamnocitrin: A Review of Pharmacology and Analytical Aspects. Drug Metab Bioanal Lett. 2022;15(3):150-158. doi: 10.2174/2949681015666220609100336. PMID: 35794741. 14: Johnson TO, Adegboyega AE, Ojo OA, Yusuf AJ, Iwaloye O, Ugwah-Oguejiofor CJ, Asomadu RO, Chukwuma IF, Ejembi SA, Ugwuja EI, Alotaibi SS, Albogami SM, Batiha GE, Rajab BS, Conte-Junior CA. A Computational Approach to Elucidate the Interactions of Chemicals From Artemisia annua Targeted Toward SARS-CoV-2 Main Protease Inhibition for COVID-19 Treatment. Front Med (Lausanne). 2022 Jun 15;9:907583. doi: 10.3389/fmed.2022.907583. PMID: 35783612; PMCID: PMC9240657. 15: Zhou Y, Lan H, Dong Z, Li W, Qian B, Zeng Z, He W, Song JL. Rhamnocitrin Attenuates Ovarian Fibrosis in Rats with Letrozole-Induced Experimental Polycystic Ovary Syndrome. Oxid Med Cell Longev. 2022 May 26;2022:5558599. doi: 10.1155/2022/5558599. PMID: 35663203; PMCID: PMC9162838. 16: Cai X, Xu X. Investigation of the key targets and pharmacological mechanisms of rhamnocitrin against oxaliplatin-induced neuropathic pain based on network pharmacology approach and experimental validation. Gen Physiol Biophys. 2022 May;41(3):191-203. doi: 10.4149/gpb_2022015. PMID: 35616000. 17: Petrisor G, Motelica L, Craciun LN, Oprea OC, Ficai D, Ficai A. Melissa officinalis: Composition, Pharmacological Effects and Derived Release Systems-A Review. Int J Mol Sci. 2022 Mar 25;23(7):3591. doi: 10.3390/ijms23073591. PMID: 35408950; PMCID: PMC8998931. 18: Punia Bangar S, Singh A, Chaudhary V, Sharma N, Lorenzo JM. Beetroot as a novel ingredient for its versatile food applications. Crit Rev Food Sci Nutr. 2023;63(26):8403-8427. doi: 10.1080/10408398.2022.2055529. Epub 2022 Mar 25. PMID: 35333666. 19: Millones Gómez PA, Tay Chu Jon LY, Maurtua Torres DJ, Bacilio Amaranto RE, Collantes Díaz IE, Minchón Medina CA, Calla Choque JS. Antibacterial, antibiofilm, and cytotoxic activities and chemical compositions of Peruvian propolis in an in vitro oral biofilm. F1000Res. 2021 Oct 27;10:1093. doi: 10.12688/f1000research.73602.2. PMID: 34853678; PMCID: PMC8613507. 20: Xie B, Wu XF, Luo HT, Huang XL, Huang F, Zhang QY, Zhou X, Wu HQ. Chemical profiling and quality evaluation of Pogostemon cablin Benth by liquid chromatography tandem mass spectrometry combined with multivariate statistical analysis. J Pharm Biomed Anal. 2022 Feb 5;209:114526. doi: 10.1016/j.jpba.2021.114526. Epub 2021 Dec 9. PMID: 34915323.