GSK690693 is a pan-AKT kinase inhibitor, is also a n aminofurazan-derived inhibitor of Akt kinases with potential antineoplastic activity. Pan-AKT kinase inhibitor GSK-690693 binds to and inhibits Akt kinases 1, 2, and 3, which may result in the inhibition of protein phosphorylation events downstream from Akt kinases in the PI3K/Akt signaling pathway, and, subsequently, the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. In addition, this agent may inhibit other protein kinases including protein kinase C (PKC) and protein kinase A (PKA). As serine/threonine protein kinases which are involved in a number of biological processes, AKT kinases promote cell survival by inhibiting apoptosis and are required for glucose transport. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
MedKoo Cat#: 205670
Name: GSK-690693
CAS#: 937174-76-0
Chemical Formula: C21H27N7O3
Exact Mass: 425.2175
Molecular Weight: 425.49
Elemental Analysis: C, 59.28; H, 6.40; N, 23.04; O, 11.28
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 25.0 | 58.76 | |
| DMF:PBS (pH 7.2) (1:1) | 0.5 | 1.18 | |
| DMSO | 26.3 | 61.85 | |
| Water | 5.0 | 11.75 |
The following data is based on the product molecular weight 425.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
