MedKoo Cat#: 466106 | Name: DQ661

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DQ661 is a PPT1 and mTORC1 inhibitor.

Chemical Structure

DQ661
DQ661
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 466106

Name: DQ661

CAS#: unknown

Chemical Formula: C41H47Cl2N5O2

Exact Mass: 711.3107

Molecular Weight: 712.76

Elemental Analysis: C, 69.09; H, 6.65; Cl, 9.95; N, 9.83; O, 4.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
DQ661; DQ 661; DQ-661;
IUPAC/Chemical Name
N1-(6-chloro-2-methoxyacridin-9-yl)-N6-(6-((6-chloro-2-methoxyacridin-9-yl)amino)hexyl)-N6-methylhexane-1,6-diamine
InChi Key
NSDQTFHPQPESSG-UHFFFAOYSA-N
InChi Code
InChI=1S/C41H47Cl2N5O2/c1-48(22-10-6-4-8-20-44-40-32-16-12-28(42)24-38(32)46-36-18-14-30(49-2)26-34(36)40)23-11-7-5-9-21-45-41-33-17-13-29(43)25-39(33)47-37-19-15-31(50-3)27-35(37)41/h12-19,24-27H,4-11,20-23H2,1-3H3,(H,44,46)(H,45,47)
SMILES Code
CN(CCCCCCNC1=C(C=CC(Cl)=C2)C2=NC3=C1C=C(OC)C=C3)CCCCCCNC4=C5C(C=CC(OC)=C5)=NC6=C4C=CC(Cl)=C6
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 712.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Allemailem KS, Almatroudi A, Alrumaihi F, Almatroodi SA, Alkurbi MO, Basfar GT, Rahmani AH, Khan AA. Novel Approaches of Dysregulating Lysosome Functions in Cancer Cells by Specific Drugs and Its Nanoformulations: A Smart Approach of Modern Therapeutics. Int J Nanomedicine. 2021 Jul 26;16:5065-5098. doi: 10.2147/IJN.S321343. PMID: 34345172; PMCID: PMC8324981. 2: Nicastri MC, Rebecca VW, Amaravadi RK, Winkler JD. Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells. Mol Cell Oncol. 2017 Nov 30;5(1):e1395504. doi: 10.1080/23723556.2017.1395504. PMID: 29404393; PMCID: PMC5791860. 3: Rebecca VW, Nicastri MC, McLaughlin N, Fennelly C, McAfee Q, Ronghe A, Nofal M, Lim CY, Witze E, Chude CI, Zhang G, Alicea GM, Piao S, Murugan S, Ojha R, Levi SM, Wei Z, Barber-Rotenberg JS, Murphy ME, Mills GB, Lu Y, Rabinowitz J, Marmorstein R, Liu Q, Liu S, Xu X, Herlyn M, Zoncu R, Brady DC, Speicher DW, Winkler JD, Amaravadi RK. A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles. Cancer Discov. 2017 Nov;7(11):1266-1283. doi: 10.1158/2159-8290.CD-17-0741. Epub 2017 Sep 12. PMID: 28899863; PMCID: PMC5833978.