MCG315 | CAS#unknown | PARP-1 inhibitor

MedKoo Cat#: 466100 | Name: MCG315

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MCG315 is a potent PARP-1 inhibitor.

Chemical Structure

MCG315

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 466100

Name: MCG315

CAS#: unknown

Chemical Formula: C10H9NO

Exact Mass: 159.0684

Molecular Weight: 159.19

Elemental Analysis: C, 75.45; H, 5.70; N, 8.80; O, 10.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

MCG315; MCG 315; MCG-315;

IUPAC/Chemical Name

2,3-dihydro-1H-benzo[c]azepin-1-one

InChi Key

UIGKDFAYPOHSRW-UHFFFAOYSA-N

InChi Code

InChI=1S/C10H9NO/c12-10-9-6-2-1-4-8(9)5-3-7-11-10/h1-6H,7H2,(H,11,12)

SMILES Code

O=C1C2=CC=CC=C2C=CCN1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 159.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Centko RM, Carlile GW, Barne I, Patrick BO, Blagojevic P, Thomas DY, Andersen RJ. Combination of Selective PARP3 and PARP16 Inhibitory Analogues of Latonduine A Corrects F508del-CFTR Trafficking. ACS Omega. 2020 Sep 29;5(40):25593-25604. doi: 10.1021/acsomega.0c02467. PMID: 33073085; PMCID: PMC7557227. 2: Carlile GW, Robert R, Matthes E, Yang Q, Solari R, Hatley R, Edge CM, Hanrahan JW, Andersen R, Thomas DY, Birault V. Latonduine Analogs Restore F508del-Cystic Fibrosis Transmembrane Conductance Regulator Trafficking through the Modulation of Poly-ADP Ribose Polymerase 3 and Poly-ADP Ribose Polymerase 16 Activity. Mol Pharmacol. 2016 Aug;90(2):65-79. doi: 10.1124/mol.115.102418. Epub 2016 May 18. PMID: 27193581.