MedKoo Cat#: 466090 | Name: CGP-49823

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CGP-49823 is a non-peptide tachykinin NK1 receptor antagonist.

Chemical Structure

CGP-49823
CGP-49823
CAS#150705-88-7

Theoretical Analysis

MedKoo Cat#: 466090

Name: CGP-49823

CAS#: 150705-88-7

Chemical Formula: C31H33N3O

Exact Mass: 463.2624

Molecular Weight: 463.63

Elemental Analysis: C, 80.31; H, 7.17; N, 9.06; O, 3.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CGP-49823; CGP49823; CGP 49823;
IUPAC/Chemical Name
{(R)-2-Benzyl-4-[(quinolin-4-ylmethyl)-amino]-piperidin-1-yl}-(3,5-dimethyl-phenyl)-methanone
InChi Key
WQZUOBIIPDZRJP-QXPUDEPPSA-N
InChi Code
InChI=1S/C31H33N3O/c1-22-16-23(2)18-26(17-22)31(35)34-15-13-27(20-28(34)19-24-8-4-3-5-9-24)33-21-25-12-14-32-30-11-7-6-10-29(25)30/h3-12,14,16-18,27-28,33H,13,15,19-21H2,1-2H3/t27-,28?/m1/s1
SMILES Code
CC1=CC(C(N2C(CC3=CC=CC=C3)C[C@H](NCC4=CC=NC5=CC=CC=C45)CC2)=O)=CC(C)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 463.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Khawaja AM, Liu Y, Rogers DF. Effect of non-peptide tachykinin NK(1) receptor antagonists on non-adrenergic, non-cholinergic neurogenic mucus secretion in ferret trachea. Eur J Pharmacol. 1999 Nov 19;384(2-3):173-81. doi: 10.1016/s0014-2999(99)00694-9. PMID: 10611439. 2: Pozza MF, Olpe HR, Ofner S, Schoeffel C, Evans RH. The potency of the novel tachykinin receptor antagonist CGP49823 at rat and gerbil motoneurones in vitro. Eur J Pharmacol. 1998 Jan 26;342(2-3):203-8. doi: 10.1016/s0014-2999(97)01500-8. PMID: 9548386. 3: File SE. Anxiolytic action of a neurokinin1 receptor antagonist in the social interaction test. Pharmacol Biochem Behav. 1997 Nov;58(3):747-52. doi: 10.1016/s0091-3057(97)90002-2. PMID: 9329068.