MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 466084 | Name: JH-XVI-178

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JH-XVI-178 is a novel highly potent and selective inhibitor of CDK8/19, displaying low clearance and moderate oral pharmacokinetic properties.

Chemical Structure

JH-XVI-178
JH-XVI-178
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 466084

Name: JH-XVI-178

CAS#: unknown

Chemical Formula: C22H22ClN7O

Exact Mass: 435.1574

Molecular Weight: 435.92

Elemental Analysis: C, 60.62; H, 5.09; Cl, 8.13; N, 22.49; O, 3.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
JH-XVI-178; JHXVI-178; JH XVI-178; JH-XVI178; JH-XVI 178; JHXVI178; JH XVI 178;
IUPAC/Chemical Name
8-(3-chloro-5-(1-methyl-1H-indazol-5-yl)-2H-pyrazolo[3,4-b]pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
InChi Key
YLJSAFSDGFNKAC-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H22ClN7O/c1-29-16-3-2-13(10-14(16)11-26-29)15-12-25-20-17(19(23)27-28-20)18(15)30-8-5-22(6-9-30)4-7-24-21(22)31/h2-3,10-12H,4-9H2,1H3,(H,24,31)(H,25,27,28)
SMILES Code
O=C1NCCC12CCN(C3=C(C4=CC5=C(N(C)N=C5)C=C4)C=NC6=NNC(Cl)=C63)CC2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 435.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hatcher JM, Vatsan PS, Wang E, Jiang J, Gray NS. Development of Highly Potent and Selective Pyrazolopyridine Inhibitor of CDK8/19. ACS Med Chem Lett. 2021 Oct 22;12(11):1689-1693. doi: 10.1021/acsmedchemlett.1c00300. PMID: 34795857; PMCID: PMC8591729.