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MedKoo Cat#: 466083 | Name: NK007(S,R)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NK007(S,R) is a natural anti-SARS-CoV-2 agent, displaying high antiviral activity against SARS-CoV-2 with an EC50 0.03 μM in vitro, which is substantially lower than that of remdesivir (EC50: 0.8 μM in vitro).

Chemical Structure

NK007(S,R)
CAS#482-20-2 (free base)

Theoretical Analysis

MedKoo Cat#: 466083

Name: NK007(S,R)

CAS#: 482-20-2 (free base)

Chemical Formula: C28H33NO9

Exact Mass: 527.2155

Molecular Weight: 527.57

Elemental Analysis: C, 63.75; H, 6.31; N, 2.66; O, 27.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NK007(S,R); NK007 (S,R); NK007-(S,R); (S,R)-Tylophorine Malate; (S,R) Tylophorine Malate; Tylophorine D-Malate;
IUPAC/Chemical Name
(S)-2,3,6,7-tetramethoxy-9,11,12,13,13a,14-hexahydrodibenzo[f,h]pyrrolo[1,2-b]isoquinoline (R)-2-hydroxysuccinate
InChi Key
TWYMIIDBMKEYEF-CVVWDYCYSA-N
InChi Code
InChI=1S/C24H27NO4.C4H6O5/c1-26-21-9-16-15-8-14-6-5-7-25(14)13-20(15)19-12-24(29-4)23(28-3)11-18(19)17(16)10-22(21)27-2;5-2(4(8)9)1-3(6)7/h9-12,14H,5-8,13H2,1-4H3;2,5H,1H2,(H,6,7)(H,8,9)/t14-;2-/m01/s1
SMILES Code
COC1=CC2=C3C(CN(CCC4)[C@@H]4C3)=C5C(C=C(OC)C(OC)=C5)=C2C=C1OC.OC(C[C@@H](O)C(O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 527.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang Z, Ye F, Feng Y, Xiao W, Song H, Zhao L, Lu R, Huang B, Liu Y, Wang W, Li Y, Ding Y, Zheng Y, Song X, Tan W, Wang Q. Discovery and Nanosized Preparations of (S,R)-Tylophorine Malate as Novel anti-SARS-CoV-2 Agents. ACS Med Chem Lett. 2021 Oct 24;12(11):1838-1844. doi: 10.1021/acsmedchemlett.1c00481. PMID: 34745429; PMCID: PMC8565188.