MedKoo Cat#: 408169 | Name: TC11
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TC11, also known as (CLT-003, is a MCL1 degrader. TC11 induces apoptosis by degrading MCL1 in multiple myeloma cells. TC11 does not induce degradation of CRBN's substrates, IKZF1/3 and CK1α, and induces apoptosis of CRBN-silenced MM; this effect was independent of the cereblon (CRBN) pathway, which is involved in the mechanism of action of immunomodulatory drugs (IMiDs) used for the treatment of MM. TC11 induces apoptotic death caused by degradation of MCL1 during prolonged mitotic arrest.

Chemical Structure

TC11
TC11
CAS# 100823-03-8

Theoretical Analysis

MedKoo Cat#: 408169

Name: TC11

CAS#: 100823-03-8

Chemical Formula: C20H22N2O2

Exact Mass: 322.1681

Molecular Weight: 322.41

Elemental Analysis: C, 74.51; H, 6.88; N, 8.69; O, 9.92

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 3,650.00 2 Weeks
2g USD 6,250.00 2 Weeks
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Related CAS #
No Data
Synonym
TC11; TC-11 ; TC 11; CLT-003; CLT 003; CLT003;
IUPAC/Chemical Name
1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-
InChi Key
O=C1N(C2=C(C(C)C)C=CC=C2C(C)C)C(C3=C1C=CC(N)=C3)=O
InChi Code
InChI=1S/C20H22N2O2/c1-11(2)14-6-5-7-15(12(3)4)18(14)22-19(23)16-9-8-13(21)10-17(16)20(22)24/h5-12H,21H2,1-4H3
SMILES Code
O=C1N(C2=C(C(C)C)C=CC=C2C(C)C)C(C3=C1C=CC(N)=C3)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 322.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Ichikawa D, Nakamura M, Murota W, Osawa S, Matsushita M, Yanagawa H, Hattori Y. A phenylphthalimide derivative, TC11, induces apoptosis by degrading MCL1 in multiple myeloma cells. Biochem Biophys Res Commun. 2020 Jan 1;521(1):252-258. doi: 10.1016/j.bbrc.2019.10.119. Epub 2019 Oct 22. PMID: 31653349.