TC11, also known as (CLT-003, is a MCL1 degrader. TC11 induces apoptosis by degrading MCL1 in multiple myeloma cells. TC11 does not induce degradation of CRBN's substrates, IKZF1/3 and CK1α, and induces apoptosis of CRBN-silenced MM; this effect was independent of the cereblon (CRBN) pathway, which is involved in the mechanism of action of immunomodulatory drugs (IMiDs) used for the treatment of MM. TC11 induces apoptotic death caused by degradation of MCL1 during prolonged mitotic arrest.
MedKoo Cat#: 408169
Name: TC11
CAS#: 100823-03-8
Chemical Formula: C20H22N2O2
Exact Mass: 322.1681
Molecular Weight: 322.41
Elemental Analysis: C, 74.51; H, 6.88; N, 8.69; O, 9.92
The following data is based on the product molecular weight 322.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |