SPH5030 is a Selective, Potent, and Irreversible Tyrosine Kinase Inhibitor (IC50 < 1 nM) for HER2-Amplified and HER2-Mutant Cancer Treatment. SPH5030 showed excellent activities against four frequent kinds of HER2 mutants and high relative HER2 selectivity compared with neratinib and pyrotinib, good pharmacokinetic characteristics with desirable bioavailabilities, and significant in vivo antitumor efficacy in xenograft mouse models, especially in a HER2 mutation A775_G776insYVMA xenograft mouse model with its potency much higher than those of neratinib and pyrotinib.
MedKoo Cat#: 466075
Name: SPH5030
CAS#: unknown
Chemical Formula: C31H31FN8O3
Exact Mass: 582.2503
Molecular Weight: 582.64
Elemental Analysis: C, 63.91; H, 5.36; F, 3.26; N, 19.23; O, 8.24
The following data is based on the product molecular weight 582.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
