5SGlcNHex is a potent inhibitor of heparanase, an endo-β-glucuronidase implicated in cancer metastasis, angiogenesis, and inflammation. In the referenced study, 5SGlcNHex demonstrated nanomolar-level inhibition of human heparanase, with an IC₅₀ value of approximately 43 nM. The compound mimics key structural features of heparan sulfate yet resists enzymatic cleavage, allowing it to competitively bind to the enzyme’s active site. In cellular assays, it effectively inhibited heparanase-mediated cell invasion and matrix degradation. These findings support 5SGlcNHex as a promising small-molecule lead for anti-metastatic and anti-inflammatory drug development.
MedKoo Cat#: 466074
Name: 5S-GlcNHex
CAS#: 1346636-43-8
Chemical Formula: C12H23NO5S
Exact Mass: 293.1297
Molecular Weight: 293.38
Elemental Analysis: C, 49.13; H, 7.90; N, 4.77; O, 27.27; S, 10.93
The following data is based on the product molecular weight 293.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
