Muricatacin, a polyketide lactone isolated from Annona muricata and related Annonaceae species, exhibits moderate cytotoxic activity, primarily against human cancer cell lines. Studies report that muricatacin inhibits the proliferation of tumor cells such as KB (human epidermoid carcinoma) and HeLa (cervical cancer) with IC₅₀ values in the low micromolar range, typically between 1–10 µM depending on the assay conditions. Its cytotoxicity is thought to arise from disruption of mitochondrial function and induction of apoptosis, although its potency is significantly lower than more complex annonaceous acetogenins. Additionally, muricatacin serves as a synthetic intermediate or pharmacophore core in medicinal chemistry research for designing more potent analogs.
MedKoo Cat#: 577835
Name: Muricatacin
CAS#: 134698-86-5
Chemical Formula: C17H32O3
Exact Mass: 284.2351
Molecular Weight: 284.44
Elemental Analysis: C, 71.79; H, 11.34; O, 16.87
The following data is based on the product molecular weight 284.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
