MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 577834 | Name: KRN-8602 hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KRN-8602 hydrochloride is a cytotoxic agent studied for use in treatment of high-grade glioma.

Chemical Structure

KRN-8602 hydrochloride
KRN-8602 hydrochloride
CAS#131722-57-1

Theoretical Analysis

MedKoo Cat#: 577834

Name: KRN-8602 hydrochloride

CAS#: 131722-57-1

Chemical Formula: C30H36ClNO11

Exact Mass: 621.1977

Molecular Weight: 622.06

Elemental Analysis: C, 57.92; H, 5.83; Cl, 5.70; N, 2.25; O, 28.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
KRN-8602 hydrochloride; KRN 8602 hydrochloride; KRN8602 hydrochloride; KRN-8602 HCl; MX2 HCl
IUPAC/Chemical Name
8-ethyl-1,6,7,8,11-pentahydroxy-10-((5-hydroxy-6-methyl-4-morpholinotetrahydro-2H-pyran-2-yl)oxy)-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride
InChi Key
ZDJRSUWWMAYYID-UHFFFAOYSA-N
InChi Code
InChI=1S/C30H35NO11.ClH/c1-3-30(39)12-17(42-18-11-15(24(33)13(2)41-18)31-7-9-40-10-8-31)20-23(29(30)38)28(37)21-22(27(20)36)26(35)19-14(25(21)34)5-4-6-16(19)32;/h4-6,13,15,17-18,24,29,32-33,36-39H,3,7-12H2,1-2H3;1H
SMILES Code
Cl.CCC1(O)CC(OC2CC(C(O)C(C)O2)N3CCOCC3)c4c(O)c5C(=O)c6c(O)cccc6C(=O)c5c(O)c4C1O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 622.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Clarke K, Basser RL, Underhill C, Mitchell P, Bartlett J, Cher L, Findlay M, Dalley D, Pell M, Byrne M, Geldard H, Hill JS, Maher D, Fox RM, Green MD, Kaye AH. KRN8602 (MX2-hydrochloride): an active new agent for the treatment of recurrent high-grade glioma. J Clin Oncol. 1999 Aug;17(8):2579-84. doi: 10.1200/JCO.1999.17.8.2579. PMID: 10561325. 2. Shinkai H, Takahashi H, Miyamoto K, Uchida T, Tokiwa T. Comparative pharmacokinetics of KRN8602, a new morpholino anthracycline, and adriamycin in tumor-bearing mice. Cancer Chemother Pharmacol. 1996;38(5):417-24. doi: 10.1007/s002800050505. PMID: 8765434. 3. Kubota T, Suto A, Josui K, Ishibiki K, Abe O, Yamada Y, Asanuma F, Kawamura E, Koh J, Shiina E, et al. Antitumor activity and pharmacokinetics of a morpholino-anthracycline derivative (KRN8602) against human breast carcinoma xenografts serially transplanted into nude mice. Jpn J Cancer Res. 1990 Aug;81(8):827-33. doi: 10.1111/j.1349-7006.1990.tb02652.x. PMID: 2144515; PMCID: PMC5918099.