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MedKoo Cat#: 466051 | Name: Anivamersen

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Anivamersen is a reversal/control agent.

Chemical Structure

Anivamersen
Anivamersen
CAS#959716-29-1

Theoretical Analysis

MedKoo Cat#: 466051

Name: Anivamersen

CAS#: 959716-29-1

Chemical Formula: C157H208N56O103P14

Exact Mass: 4958.9086

Molecular Weight: 4961.31

Elemental Analysis: C, 38.01; H, 4.23; N, 15.81; O, 33.21; P, 8.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Anivamersen; RB007; RB-007; RB 007;
IUPAC/Chemical Name
N/A
InChi Key
DJMVASRJWAOIAN-UHFFFAOYSA-N
InChi Code
InChI=1S/C157H208N56O103P14/c1-259-102-87(218)58(289-131(102)199-24-16-72(158)183-150(199)223)33-274-317(231,232)310-95-65(296-139(110(95)267-9)207-50-176-80-117(163)170-47-173-120(80)207)40-282-321(239,240)305-90-60(291-134(105(90)262-4)202-27-19-75(161)186-153(202)226)34-276-319(235,236)304-89-59(290-133(104(89)261-3)201-26-18-74(160)185-152(201)225)35-277-320(237,238)307-92-63(294-136(107(92)264-6)204-29-21-77(215)188-155(204)228)38-280-327(251,252)314-99-70(301-143(114(99)271-13)211-54-180-84-124(211)192-147(167)196-128(84)220)45-286-329(255,256)312-97-67(298-141(112(97)269-11)209-52-178-82-119(165)172-49-175-122(82)209)42-284-323(243,244)308-93-62(293-137(108(93)265-7)205-30-22-78(216)189-156(205)229)37-279-325(247,248)311-96-66(297-140(111(96)268-10)208-51-177-81-118(164)171-48-174-121(81)208)41-283-322(241,242)309-94-64(295-138(109(94)266-8)206-31-23-79(217)190-157(206)230)39-281-328(253,254)315-100-71(302-144(115(100)272-14)212-55-181-85-125(212)193-148(168)197-129(85)221)46-287-330(257,258)316-101-69(300-145(116(101)273-15)213-56-182-86-126(213)194-149(169)198-130(86)222)44-285-324(245,246)306-91-61(292-135(106(91)263-5)203-28-20-76(162)187-154(203)227)36-278-326(249,250)313-98-68(299-142(113(98)270-12)210-53-179-83-123(210)191-146(166)195-127(83)219)43-275-318(233,234)303-88-57(32-214)288-132(103(88)260-2)200-25-17-73(159)184-151(200)224/h16-31,47-71,87-116,131-145,214,218H,32-46H2,1-15H3,(H,231,232)(H,233,234)(H,235,236)(H,237,238)(H,239,240)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H2,158,183,223)(H2,159,184,224)(H2,160,185,225)(H2,161,186,226)(H2,162,187,227)(H2,163,170,173)(H2,164,171,174)(H2,165,172,175)(H,188,215,228)(H,189,216,229)(H,190,217,230)(H3,166,191,195,219)(H3,167,192,196,220)(H3,168,193,197,221)(H3,169,194,198,222)
SMILES Code
COC1C(O)C(COP(O)(OC2C(COP(O)(OC3C(COP(O)(OC4C(COP(O)(OC5C(COP(O)(OC6C(COP(O)(OC7C(COP(O)(OC8C(COP(O)(OC9C(COP(O)(OC%10C(COP(O)(OC%11C(COP(O)(OC%12C(COP(O)(OC%13C(COP(O)(OC%14C(COP(O)(OC%15C(CO)OC(N%16C=CC(N)=NC%16=O)C%15OC)=O)OC(N%17C=NC%18=C%17N=C(N)NC%18=O)C%14OC)=O)OC(N%19C=CC(N)=NC%19=O)C%13OC)=O)OC(N%20C=NC%21=C%20N=C(N)NC%21=O)C%12OC)=O)OC(N%22C=NC%23=C%22N=C(N)NC%23=O)C%11OC)=O)OC(N%24C=CC(NC%24=O)=O)C%10OC)=O)OC(N%25C=NC%26=C(N)N=CN=C%26%25)C9OC)=O)OC(N%27C=CC(NC%27=O)=O)C8OC)=O)OC(N%28C=NC%29=C(N)N=CN=C%29%28)C7OC)=O)OC(N%30C=NC%31=C%30N=C(N)NC%31=O)C6OC)=O)OC(N%32C=CC(NC%32=O)=O)C5OC)=O)OC(N%33C=CC(N)=NC%33=O)C4OC)=O)OC(N%34C=CC(N)=NC%34=O)C3OC)=O)OC(N%35C=NC%36=C(N)N=CN=C%36%35)C2OC)=O)OC1N%37C=CC(N)=NC%37=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 4,961.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Jain S, Kaur J, Prasad S, Roy I. Nucleic acid therapeutics: a focus on the development of aptamers. Expert Opin Drug Discov. 2021 Mar;16(3):255-274. doi: 10.1080/17460441.2021.1829587. Epub 2020 Oct 15. PMID: 32990095. 2: Staudacher DL, Putz V, Heger L, Reinöhl J, Hortmann M, Zelenkofske SL, Becker RC, Rusconi CP, Bode C, Ahrens I. Direct factor IXa inhibition with the RNA- aptamer pegnivacogin reduces platelet reactivity in vitro and residual platelet aggregation in patients with acute coronary syndromes. Eur Heart J Acute Cardiovasc Care. 2019 Sep;8(6):520-526. doi: 10.1177/2048872617703065. Epub 2017 Apr 13. PMID: 28403626. 3: Lincoff AM, Mehran R, Povsic TJ, Zelenkofske SL, Huang Z, Armstrong PW, Steg PG, Bode C, Cohen MG, Buller C, Laanmets P, Valgimigli M, Marandi T, Fridrich V, Cantor WJ, Merkely B, Lopez-Sendon J, Cornel JH, Kasprzak JD, Aschermann M, Guetta V, Morais J, Sinnaeve PR, Huber K, Stables R, Sellers MA, Borgman M, Glenn L, Levinson AI, Lopes RD, Hasselblad V, Becker RC, Alexander JH; REGULATE- PCI Investigators. Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial. Lancet. 2016 Jan 23;387(10016):349-356. doi: 10.1016/S0140-6736(15)00515-2. Epub 2015 Nov 5. Erratum in: Lancet. 2016 Mar 19;387(10024):1162. Boudoulas, Dean [corrected to Boudoulas, Konstantinos D.]. PMID: 26547100. 4: Bel A, Borik W, Davidson S, Helies JM, Stimmer L, Fremes S, Zelenkofske S, Rusconi C, Alexander J, Alexander D, Menasché P, Pepper J. Inhibition of factor IXa by the pegnivacogin system during cardiopulmonary bypass: a potential substitute for heparin. A study in baboons. Eur J Cardiothorac Surg. 2016 Feb;49(2):682-9. doi: 10.1093/ejcts/ezv159. Epub 2015 May 7. PMID: 25953802. 5: Gomez-Outes A, Suarez-Gea ML, Lecumberri R, Terleira-Fernandez AI, Vargas- Castrillon E. Specific antidotes in development for reversal of novel anticoagulants: a review. Recent Pat Cardiovasc Drug Discov. 2014;9(1):2-10. doi: 10.2174/1574890109666141205132531. PMID: 25494843. 6: Povsic TJ, Vavalle JP, Alexander JH, Aberle LH, Zelenkofske SL, Becker RC, Buller CE, Cohen MG, Cornel JH, Kasprzak JD, Montalescot G, Fail PS, Sarembock IJ, Mehran R; RADAR Investigators. Use of the REG1 anticoagulation system in patients with acute coronary syndromes undergoing percutaneous coronary intervention: results from the phase II RADAR-PCI study. EuroIntervention. 2014 Aug;10(4):431-8. doi: 10.4244/EIJY14M06_01. PMID: 24929350. 7: Vavalle JP, Rusconi CP, Zelenkofske S, Wargin WA, Ortel TL, Alexander JH, Povsic TJ, Becker RC. The effect of the REG2 Anticoagulation System on thrombin generation kinetics: a pharmacodynamic and pharmacokinetic first-in-human study. J Thromb Thrombolysis. 2014 Oct;38(3):275-84. doi: 10.1007/s11239-014-1081-6. PMID: 24880800. 8: Povsic TJ, Vavalle JP, Aberle LH, Kasprzak JD, Cohen MG, Mehran R, Bode C, Buller CE, Montalescot G, Cornel JH, Rynkiewicz A, Ring ME, Zeymer U, Natarajan M, Delarche N, Zelenkofske SL, Becker RC, Alexander JH; RADAR Investigators. A Phase 2, randomized, partially blinded, active-controlled study assessing the efficacy and safety of variable anticoagulation reversal using the REG1 system in patients with acute coronary syndromes: results of the RADAR trial. Eur Heart J. 2013 Aug;34(31):2481-9. doi: 10.1093/eurheartj/ehs232. Epub 2012 Aug 2. PMID: 22859796; PMCID: PMC3895957. 9: Vavalle JP, Rusconi CP, Zelenkofske S, Wargin WA, Alexander JH, Becker RC. A phase 1 ascending dose study of a subcutaneously administered factor IXa inhibitor and its active control agent. J Thromb Haemost. 2012 Jul;10(7):1303-11. doi: 10.1111/j.1538-7836.2012.04742.x. PMID: 22500821. 10: Povsic TJ, Wargin WA, Alexander JH, Krasnow J, Krolick M, Cohen MG, Mehran R, Buller CE, Bode C, Zelenkofske SL, Rusconi CP, Becker RC; RADAR Investigators. Pegnivacogin results in near complete FIX inhibition in acute coronary syndrome patients: RADAR pharmacokinetic and pharmacodynamic substudy. Eur Heart J. 2011 Oct;32(19):2412-9. doi: 10.1093/eurheartj/ehr179. Epub 2011 Jun 30. PMID: 21724623. 11: Povsic TJ, Cohen MG, Chan MY, Zelenkofske SL, Wargin WA, Harrington RA, Alexander JH, Rusconi CP, Becker RC. Dose selection for a direct and selective factor IXa inhibitor and its complementary reversal agent: translating pharmacokinetic and pharmacodynamic properties of the REG1 system to clinical trial design. J Thromb Thrombolysis. 2011 Jul;32(1):21-31. doi: 10.1007/s11239-011-0588-3. PMID: 21503856. 12: Povsic TJ, Cohen MG, Mehran R, Buller CE, Bode C, Cornel JH, Kasprzak JD, Montalescot G, Joseph D, Wargin WA, Rusconi CP, Zelenkofske SL, Becker RC, Alexander JH. A randomized, partially blinded, multicenter, active-controlled, dose-ranging study assessing the safety, efficacy, and pharmacodynamics of the REG1 anticoagulation system in patients with acute coronary syndromes: design and rationale of the RADAR Phase IIb trial. Am Heart J. 2011 Feb;161(2):261-268.e1-2. doi: 10.1016/j.ahj.2010.10.022. PMID: 21315207. 13: Povsic TJ, Sullenger BA, Zelenkofske SL, Rusconi CP, Becker RC. Translating nucleic acid aptamers to antithrombotic drugs in cardiovascular medicine. J Cardiovasc Transl Res. 2010 Dec;3(6):704-16. doi: 10.1007/s12265-010-9230-6. Epub 2010 Nov 16. PMID: 21080135. 14: Cohen MG, Purdy DA, Rossi JS, Grinfeld LR, Myles SK, Aberle LH, Greenbaum AB, Fry E, Chan MY, Tonkens RM, Zelenkofske S, Alexander JH, Harrington RA, Rusconi CP, Becker RC. First clinical application of an actively reversible direct factor IXa inhibitor as an anticoagulation strategy in patients undergoing percutaneous coronary intervention. Circulation. 2010 Aug 10;122(6):614-22. doi: 10.1161/CIRCULATIONAHA.109.927756. Epub 2010 Jul 26. PMID: 20660806. 15: Becker RC, Chan MY. REG-1, a regimen comprising RB-006, a Factor IXa antagonist, and its oligonucleotide active control agent RB-007 for the potential treatment of arterial thrombosis. Curr Opin Mol Ther. 2009 Dec;11(6):707-15. PMID: 20072947. 16: Tanaka KA, Szlam F, Rusconi CP, Levy JH. In-vitro evaluation of anti-factor IXa aptamer on thrombin generation, clotting time, and viscoelastometry. Thromb Haemost. 2009 May;101(5):827-33. PMID: 19404534. 17: Tomillero A, Moral MA. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2008 Oct;30(8):643-72. PMID: 19088949. 18: Chan MY, Cohen MG, Dyke CK, Myles SK, Aberle LG, Lin M, Walder J, Steinhubl SR, Gilchrist IC, Kleiman NS, Vorchheimer DA, Chronos N, Melloni C, Alexander JH, Harrington RA, Tonkens RM, Becker RC, Rusconi CP. Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease. Circulation. 2008 Jun 3;117(22):2865-74. doi: 10.1161/CIRCULATIONAHA.107.745687. Epub 2008 May 27. PMID: 18506005. 19: Chan MY, Rusconi CP, Alexander JH, Tonkens RM, Harrington RA, Becker RC. A randomized, repeat-dose, pharmacodynamic and safety study of an antidote- controlled factor IXa inhibitor. J Thromb Haemost. 2008 May;6(5):789-96. doi: 10.1111/j.1538-7836.2008.02932.x. Epub 2008 Feb 18. PMID: 18284597. 20: Dyke CK, Steinhubl SR, Kleiman NS, Cannon RO, Aberle LG, Lin M, Myles SK, Melloni C, Harrington RA, Alexander JH, Becker RC, Rusconi CP. First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: a phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity. Circulation. 2006 Dec 5;114(23):2490-7. doi: 10.1161/CIRCULATIONAHA.106.668434. Epub 2006 Nov 13. PMID: 17101847.

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