PFI-7 is a novel, potent, cell active chemical probe for the E3 ligase GID4, binding potently to GID4 with KD = 0.08 μM (SPR) and displacing the known degron1 peptide in a NanoBRETTM assay with EC50 = 0.6 μM.
MedKoo Cat#: 466042
Name: PFI-7
CAS#: N/A
Chemical Formula: C24H27N5O
Exact Mass: 401.2216
Molecular Weight: 401.51
Elemental Analysis: C, 71.79; H, 6.78; N, 17.44; O, 3.98
The following data is based on the product molecular weight 401.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
