IOWH032 is a CFTR inhibitor. Diarrhea, a disease of poverty and poor sanitation, kills an estimated two million children each year. Oral rehydration therapy is a very simple and inexpensive treatment that has significantly reduced mortality from secretory diarrhea caused by rotavirus, cholera and enterotoxigenic Escherichia coli. The efficacy and adoption of oral rehydration therapy would be enhanced by a drug that reduces fluid loss associated with these diseases and alleviates disease symptoms. Secretion and absorption by the intestine offer a number of potential drug targets to reduce fluid loss.
MedKoo Cat#: 510267
Name: IOWH032
CAS#: 1191252-49-9
Chemical Formula: C22H15Br2N3O4
Exact Mass: 542.9429
Molecular Weight: 545.19
Elemental Analysis: C, 48.47; H, 2.77; Br, 29.31; N, 7.71; O, 11.74
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 30.0 | 55.03 | |
| DMSO | 76.7 | 140.62 | |
| DMSO:PBS (pH 7.2) (1:4) | 0.2 | 0.37 |
The following data is based on the product molecular weight 545.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
