MedKoo Cat#: 466027 | Name: RTI-97

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RTI-97 is a novel potent and selective KOR antagonist.

Chemical Structure

RTI-97
RTI-97
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 466027

Name: RTI-97

CAS#: unknown

Chemical Formula: C29H41N3O3

Exact Mass: 479.3148

Molecular Weight: 479.67

Elemental Analysis: C, 72.62; H, 8.62; N, 8.76; O, 10.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
RTI-97; RTI 97; RTI97;
IUPAC/Chemical Name
(R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)-3-methylbutan-2-yl)-2-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
InChi Key
OHIFKDNMHSXJFA-XAOJMSMDSA-N
InChi Code
InChI=1S/C29H41N3O3/c1-19(2)26(30-28(35)27-14-21-9-10-25(34)13-22(21)17-31(27)5)18-32-12-11-29(4,20(3)16-32)23-7-6-8-24(33)15-23/h6-10,13,15,19-20,26-27,33-34H,11-12,14,16-18H2,1-5H3,(H,30,35)/t20-,26+,27+,29+/m0/s1
SMILES Code
O=C([C@@H]1N(C)CC2=C(C=CC(O)=C2)C1)N[C@@H](C(C)C)CN3C[C@H](C)[C@](C)(C4=CC=CC(O)=C4)CC3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 479.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fillesoye F, Ibazizène M, Marie N, Noble F, Perrio C. Evaluation of Specific Binding of [11C]RTI-97 to Kappa Opioid Receptor by Autoradiography and PET Imaging in Rat. ACS Med Chem Lett. 2021 Oct 19;12(11):1739-1744. doi: 10.1021/acsmedchemlett.1c00369. PMID: 34795862; PMCID: PMC8591749. 2: Owens SM, Pollard GT, Howard JL, Fennell TR, Snyder RW, Carroll FI. Pharmacodynamic Relationships between Duration of Action of JDTic-like Kappa- Opioid Receptor Antagonists and Their Brain and Plasma Pharmacokinetics in Rats. ACS Chem Neurosci. 2016 Dec 21;7(12):1737-1745. doi: 10.1021/acschemneuro.6b00249. Epub 2016 Oct 4. PMID: 27700049; PMCID: PMC6532972.