YycG inhibitor 16 | CAS#506429-34-1 | YycG inhibitor

MedKoo Cat#: 466023 | Name: YycG inhibitor 16

Description:

WARNING: This product is for research use only, not for human or veterinary use.

YycG inhibitor 16 is a novel YycG inhibitor, inhibiting planktonic cells of E. faecalis, including the vancomycin- or linezolid-resistant strains.

Chemical Structure

YycG inhibitor 16

CAS#506429-34-1

Theoretical Analysis

MedKoo Cat#: 466023

Name: YycG inhibitor 16

CAS#: 506429-34-1

Chemical Formula: C30H33N3O5S

Exact Mass: 547.2141

Molecular Weight: 547.67

Elemental Analysis: C, 65.79; H, 6.07; N, 7.67; O, 14.61; S, 5.85

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

YycG inhibitor 16; Yyc-G inhibitor 16; Yyc G inhibitor 16;

IUPAC/Chemical Name

ethyl 2-((4-methylpiperazin-1-yl)methyl)-1-phenyl-5-(tosyloxy)-1H-indole-3-carboxylate

InChi Key

ASVHIXQPSDYYMK-UHFFFAOYSA-N

InChi Code

InChI=1S/C30H33N3O5S/c1-4-37-30(34)29-26-20-24(38-39(35,36)25-13-10-22(2)11-14-25)12-15-27(26)33(23-8-6-5-7-9-23)28(29)21-32-18-16-31(3)17-19-32/h5-15,20H,4,16-19,21H2,1-3H3

SMILES Code

O=C(C1=C(CN2CCN(C)CC2)N(C3=CC=CC=C3)C4=C1C=C(OS(=O)(C5=CC=C(C)C=C5)=O)C=C4)OCC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 547.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Chen Z, Xiong Y, Tang Y, Zhao Y, Chen J, Zheng J, Wu Y, Deng Q, Qu D, Yu Z. In vitro activities of thiazolidione derivatives combined with daptomycin against clinical Enterococcus faecium strains. BMC Microbiol. 2022 Jan 7;22(1):16. doi: 10.1186/s12866-021-02423-8. PMID: 34996348; PMCID: PMC8740470. 2: Chen Z, Song K, Shang Y, Xiong Y, Lyu Z, Chen J, Zheng J, Li P, Wu Y, Gu C, Xie Y, Deng Q, Yu Z, Zhang J, Qu D. Selection and Identification of Novel Antibacterial Agents against Planktonic Growth and Biofilm Formation of Enterococcus faecalis. J Med Chem. 2021 Oct 28;64(20):15037-15052. doi: 10.1021/acs.jmedchem.1c00939. Epub 2021 Oct 16. PMID: 34657423. 3: Al Akeel R, Mateen A, Syed R, Alqahtani MS, Alqahtani AS. Alanine rich peptide from Populus trichocarpa inhibit growth of Staphylococcus aureus via targetting its extracellular domain of Sensor Histidine Kinase YycGex protein. Microb Pathog. 2018 Aug;121:115-122. doi: 10.1016/j.micpath.2018.05.010. Epub 2018 May 25. PMID: 29758266. 4: Gotoh Y, Doi A, Furuta E, Dubrac S, Ishizaki Y, Okada M, Igarashi M, Misawa N, Yoshikawa H, Okajima T, Msadek T, Utsumi R. Novel antibacterial compounds specifically targeting the essential WalR response regulator. J Antibiot (Tokyo). 2010 Mar;63(3):127-34. doi: 10.1038/ja.2010.4. Epub 2010 Jan 29. PMID: 20111065. 5: Okada A, Igarashi M, Okajima T, Kinoshita N, Umekita M, Sawa R, Inoue K, Watanabe T, Doi A, Martin A, Quinn J, Nishimura Y, Utsumi R. Walkmycin B targets WalK (YycG), a histidine kinase essential for bacterial cell growth. J Antibiot (Tokyo). 2010 Feb;63(2):89-94. doi: 10.1038/ja.2009.128. Epub 2010 Jan 8. PMID: 20057515