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MedKoo Cat#: 466019 | Name: Flufenacet

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Flufenacet is a herbicide, inhibiting very-long-chain fatty acid elongase (VLCFAE) synthesis.

Chemical Structure

Flufenacet
Flufenacet
CAS#142459-58-3

Theoretical Analysis

MedKoo Cat#: 466019

Name: Flufenacet

CAS#: 142459-58-3

Chemical Formula: C14H13F4N3O2S

Exact Mass: 363.0665

Molecular Weight: 363.33

Elemental Analysis: C, 46.28; H, 3.61; F, 20.92; N, 11.57; O, 8.81; S, 8.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Flufenacet; Thiafluamide; Fluthiamide; FOE5043; FOE 5043; FOE-5043; FNC;
IUPAC/Chemical Name
N-(4-fluorophenyl)-N-isopropyl-2-((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)oxy)acetamide
InChi Key
IANUJLZYFUDJIH-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H13F4N3O2S/c1-8(2)21(10-5-3-9(15)4-6-10)11(22)7-23-13-20-19-12(24-13)14(16,17)18/h3-6,8H,7H2,1-2H3
SMILES Code
O=C(N(C1=CC=C(F)C=C1)C(C)C)COC2=NN=C(C(F)(F)F)S2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 363.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wijewardene L, Wu N, Hörmann G, Messyasz B, Riis T, Hölzel C, Ulrich U, Fohrer N. Effects of the herbicides metazachlor and flufenacet on phytoplankton communities - A microcosm assay. Ecotoxicol Environ Saf. 2021 Nov 30;228:113036. doi: 10.1016/j.ecoenv.2021.113036. Epub ahead of print. PMID: 34861440. 2: Slaby S, Le Cor F, Dufour V, Auger L, Pasquini L, Cardoso O, Curtet L, Baudoin JM, Wiest L, Vulliet E, Feidt C, Dauchy X, Banas D. Distribution of pesticides and some of their transformation products in a small lentic waterbody: Fish, water, and sediment contamination in an agricultural watershed. Environ Pollut. 2022 Jan 1;292(Pt B):118403. doi: 10.1016/j.envpol.2021.118403. Epub 2021 Oct 23. PMID: 34699920. 3: Halbach K, Möder M, Schrader S, Liebmann L, Schäfer RB, Schneeweiss A, Schreiner VC, Vormeier P, Weisner O, Liess M, Reemtsma T. Small streams-large concentrations? Pesticide monitoring in small agricultural streams in Germany during dry weather and rainfall. Water Res. 2021 Sep 15;203:117535. doi: 10.1016/j.watres.2021.117535. Epub 2021 Aug 8. PMID: 34403843. 4: Ulrich U, Pfannerstill M, Ostendorp G, Fohrer N. Omnipresent distribution of herbicides and their transformation products in all water body types of an agricultural landscape in the North German Lowland. Environ Sci Pollut Res Int. 2021 Aug;28(32):44183-44199. doi: 10.1007/s11356-021-13626-x. Epub 2021 Apr 13. PMID: 33847885; PMCID: PMC8357661. 5: Willkommen S, Lange J, Ulrich U, Pfannerstill M, Fohrer N. Field insights into leaching and transformation of pesticides and fluorescent tracers in agricultural soil. Sci Total Environ. 2021 Jan 10;751:141658. doi: 10.1016/j.scitotenv.2020.141658. Epub 2020 Aug 13. PMID: 32871316. 6: Ngow Z, Chynoweth RJ, Gunnarsson M, Rolston P, Buddenhagen CE. A herbicide resistance risk assessment for weeds in wheat and barley crops in New Zealand. PLoS One. 2020 Jun 25;15(6):e0234771. doi: 10.1371/journal.pone.0234771. PMID: 32584914; PMCID: PMC7316288. 7: Marín-Benito JM, Carpio MJ, Mamy L, Andrades MS, Sánchez-Martín MJ, Rodríguez-Cruz MS. Field measurement and modelling of chlorotoluron and flufenacet persistence in unamended and amended soils. Sci Total Environ. 2020 Jul 10;725:138374. doi: 10.1016/j.scitotenv.2020.138374. Epub 2020 Apr 1. PMID: 32278182. 8: Carpio MJ, Rodríguez-Cruz MS, García-Delgado C, Sánchez-Martín MJ, Marín- Benito JM. Mobility monitoring of two herbicides in amended soils: A field study for modeling applications. J Environ Manage. 2020 Apr 15;260:110161. doi: 10.1016/j.jenvman.2020.110161. Epub 2020 Jan 24. PMID: 32090848. 9: Marín-Benito JM, Mamy L, Carpio MJ, Sánchez-Martín MJ, Rodríguez-Cruz MS. Modelling herbicides mobility in amended soils: Calibration and test of PRZM and MACRO. Sci Total Environ. 2020 May 15;717:137019. doi: 10.1016/j.scitotenv.2020.137019. Epub 2020 Jan 30. PMID: 32070888. 10: Tomkiel M, Baćmaga M, Borowik A, Kucharski J, Wyszkowska J. Effect of a mixture of flufenacet and isoxaflutole on population numbers of soil-dwelling microorganisms, enzymatic activity of soil, and maize yield. J Environ Sci Health B. 2019;54(10):832-842. doi: 10.1080/03601234.2019.1636601. Epub 2019 Jul 7. PMID: 31280652. 11: Dücker R, Zöllner P, Lümmen P, Ries S, Collavo A, Beffa R. Glutathione transferase plays a major role in flufenacet resistance of ryegrass (Lolium spp.) field populations. Pest Manag Sci. 2019 Nov;75(11):3084-3092. doi: 10.1002/ps.5425. Epub 2019 Apr 29. PMID: 30920141. 12: Dücker R, Zöllner P, Parcharidou E, Ries S, Lorentz L, Beffa R. Enhanced metabolism causes reduced flufenacet sensitivity in black-grass (Alopecurus myosuroides Huds.) field populations. Pest Manag Sci. 2019 Nov;75(11):2996-3004. doi: 10.1002/ps.5414. Epub 2019 Apr 29. PMID: 30891919. 13: Imai M, Takagi N, Yoshizaki M, Hosokai E, Kobayashi Y. [Determination of Flufenacet and Its Metabolites in Agricultural Products by LC-MS/MS]. Shokuhin Eiseigaku Zasshi. 2019;60(1):1-6. Japanese. doi: 10.3358/shokueishi.60.1. PMID: 30814420. 14: Marín-Benito JM, Carpio MJ, Sánchez-Martín MJ, Rodríguez-Cruz MS. Previous degradation study of two herbicides to simulate their fate in a sandy loam soil: Effect of the temperature and the organic amendments. Sci Total Environ. 2019 Feb 25;653:1301-1310. doi: 10.1016/j.scitotenv.2018.11.015. Epub 2018 Nov 5. PMID: 30759570. 15: Ulrich U, Hörmann G, Unger M, Pfannerstill M, Steinmann F, Fohrer N. Lentic small water bodies: Variability of pesticide transport and transformation patterns. Sci Total Environ. 2018 Mar 15;618:26-38. doi: 10.1016/j.scitotenv.2017.11.032. Epub 2017 Nov 9. PMID: 29128775. 16: Metcalfe H, Milne AE, Hull R, Murdoch AJ, Storkey J. The implications of spatially variable pre-emergence herbicide efficacy for weed management. Pest Manag Sci. 2018 Mar;74(3):755-765. doi: 10.1002/ps.4784. Epub 2017 Dec 14. PMID: 29095563; PMCID: PMC5814844. 17: Scheurer M, Nödler K, Freeling F, Janda J, Happel O, Riegel M, Müller U, Storck FR, Fleig M, Lange FT, Brunsch A, Brauch HJ. Small, mobile, persistent: Trifluoroacetate in the water cycle - Overlooked sources, pathways, and consequences for drinking water supply. Water Res. 2017 Dec 1;126:460-471. doi: 10.1016/j.watres.2017.09.045. Epub 2017 Sep 26. PMID: 28992593. 18: Kucharski J, Tomkiel M, Baćmaga M, Borowik A, Wyszkowska J. Enzyme activity and microorganisms diversity in soil contaminated with the Boreal 58 WG herbicide. J Environ Sci Health B. 2016 Jul 2;51(7):446-54. doi: 10.1080/03601234.2016.1159456. Epub 2016 Apr 6. PMID: 27050595. 19: Wang D, Zhang Q, Zheng Y, Lin D, Yu Y. Estimating the combined toxicity of flufenacet and imazaquin to sorghum with pore water herbicide concentration. J Environ Sci (China). 2016 Mar;41:154-161. doi: 10.1016/j.jes.2015.04.031. Epub 2015 Aug 29. PMID: 26969061. 20: Mukaida S, Ogawa T, Ohishi K, Tanizawa Y, Ohta D, Arita M. The effect of rapamycin on biodiesel-producing protist Euglena gracilis. Biosci Biotechnol Biochem. 2016 Jun;80(6):1223-9. doi: 10.1080/09168451.2016.1141040. Epub 2016 Feb 12. PMID: 26872547