MedKoo Cat#: 577802 | Name: MTP-38

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MTP-38 is a biochemical that can be radiosynthesized to create a PET ligand for PDE7.

Chemical Structure

MTP-38
MTP-38
CAS#2199495-32-2

Theoretical Analysis

MedKoo Cat#: 577802

Name: MTP-38

CAS#: 2199495-32-2

Chemical Formula: C13H17N7

Exact Mass: 271.1545

Molecular Weight: 271.33

Elemental Analysis: C, 57.55; H, 6.32; N, 36.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MTP-38; MTP 38; MTP38
IUPAC/Chemical Name
8-Amino-3-(2S*,5R*-dimethyl-1-piperidyl)-(1,2,4)triazolo(4,3-a)pyrazine-5-carbonitrile
InChi Key
RJJSDWXUROOWBO-BDAKNGLRSA-N
InChi Code
1S/C13H17N7/c1-8-3-4-9(2)19(7-8)13-18-17-12-11(15)16-6-10(5-14)20(12)13/h6,8-9H,3-4,7H2,1-2H3,(H2,15,16)/t8-,9+/m1/s1
SMILES Code
C[C@@H]1CC[C@H](C)N(C1)c2nnc3c(N)ncc(C#N)n23
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 271.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Kubota M, Seki C, Kimura Y, Takahata K, Shimada H, Takado Y, Matsuoka K, Tagai K, Sano Y, Yamamoto Y, Okada M, Kikuchi T, Ichise M, Kawamura K, Zhang MR, Higuchi M. A first-in-human study of 11C-MTP38, a novel PET ligand for phosphodiesterase 7. Eur J Nucl Med Mol Imaging. 2021 Aug;48(9):2846-2855. doi: 10.1007/s00259-021-05235-0. Epub 2021 Feb 10. PMID: 33566152; PMCID: PMC8263543. 2. Obokata N, Seki C, Hirata T, Maeda J, Ishii H, Nagai Y, Matsumura T, Takakuwa M, Fukuda H, Minamimoto T, Kawamura K, Zhang MR, Nakajima T, Saijo T, Higuchi M. Synthesis and preclinical evaluation of [11C]MTP38 as a novel PET ligand for phosphodiesterase 7 in the brain. Eur J Nucl Med Mol Imaging. 2021 Sep;48(10):3101-3112. doi: 10.1007/s00259-021-05269-4. Epub 2021 Mar 5. PMID: 33674894; PMCID: PMC8426238. 3. Kawamura K, Hashimoto H, Ohkubo T, Hanyu M, Ogawa M, Nengaki N, Arashi D, Kurihara Y, Fujishiro T, Togashi T, Sakai T, Muto M, Takei M, Ishii H, Saijo T, Matsumura T, Obokata N, Zhang MR. Automated radiosynthesis of [11 C]MTP38-a phosphodiesterase 7 imaging tracer-using [11 C]hydrogen cyanide for clinical applications. J Labelled Comp Radiopharm. 2022 Feb 4. doi: 10.1002/jlcr.3965. Epub ahead of print. PMID: 35122288.