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MedKoo Cat#: 577794 | Name: MSX-3 free acid

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MSX-3 free acid is an A2A adenosine receptor antagonist and a prodrug of MSX-2.

Chemical Structure

MSX-3 free acid
MSX-3 free acid
CAS#261705-79-7

Theoretical Analysis

MedKoo Cat#: 577794

Name: MSX-3 free acid

CAS#: 261705-79-7

Chemical Formula: C21H23N4O7P

Exact Mass: 474.1304

Molecular Weight: 474.41

Elemental Analysis: C, 53.17; H, 4.89; N, 11.81; O, 23.61; P, 6.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
MSX-3 free acid; MSX 3 free acid; MSX3 free acid
IUPAC/Chemical Name
1H-Purine-2,6-dione, 3,7-dihydro-8-((1E)-2-(3-methoxyphenyl)ethenyl)-7-methyl-3-(3-(phosphonooxy)propyl)-1-(2-propyn-1-yl)-
InChi Key
DUCGTTGSVYZHJS-MDZDMXLPSA-N
InChi Code
1S/C21H23N4O7P/c1-4-11-25-20(26)18-19(24(21(25)27)12-6-13-32-33(28,29)30)22-17(23(18)2)10-9-15-7-5-8-16(14-15)31-3/h1,5,7-10,14H,6,11-13H2,2-3H3,(H2,28,29,30)/b10-9+
SMILES Code
COc1cccc(\C=C\c2nc3N(CCCOP(=O)(O)O)C(=O)N(CC#C)C(=O)c3n2C)c1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 474.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Worden LT, Shahriari M, Farrar AM, Sink KS, Hockemeyer J, Müller CE, Salamone JD. The adenosine A2A antagonist MSX-3 reverses the effort-related effects of dopamine blockade: differential interaction with D1 and D2 family antagonists. Psychopharmacology (Berl). 2009 Apr;203(3):489-99. doi: 10.1007/s00213-008-1396-0. Epub 2008 Dec 2. PMID: 19048234; PMCID: PMC2875246. 2. Salamone JD, Betz AJ, Ishiwari K, Felsted J, Madson L, Mirante B, Clark K, Font L, Korbey S, Sager TN, Hockemeyer J, Muller CE. Tremorolytic effects of adenosine A2A antagonists: implications for parkinsonism. Front Biosci. 2008 May 1;13:3594-605. doi: 10.2741/2952. PMID: 18508458.