CP17 is a highly potent degrader against EGFR L858R/T790M and EGFRdel19, reaching the lowest DC50 values among all reported EGFR-targeting PROTACs. CP17 exhibited excellent cellular activity against the H1975 and HCC827 cell lines with high selectivity. Mechanism investigation indicated that the lysosome was involved in the degradation process.
MedKoo Cat#: 466010
Name: CP17
CAS#: unknown
Chemical Formula: C54H65N13O5S
Exact Mass: 1007.4952
Molecular Weight: 1008.26
Elemental Analysis: C, 64.33; H, 6.50; N, 18.06; O, 7.93; S, 3.18
The following data is based on the product molecular weight 1,008.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
