BRD4770 is a novel histone methyltransferase inhibitor. BRD4770 reduced cellular levels of di- and trimethylated H3K9 without inducing apoptosis, induced senescence, and inhibited both anchorage-dependent and -independent proliferation in the pancreatic cancer cell line PANC-1. ATM-pathway activation, caused by either genetic or small-molecule inhibition of G9a, may mediate BRD4770-induced cell senescence. BRD4770 may be a useful tool to study G9a and its role in senescence and cancer cell biology.
MedKoo Cat#: 406572
Name: BRD4770
CAS#: 1374601-40-7
Chemical Formula: C25H23N3O3
Exact Mass: 413.1739
Molecular Weight: 413.47
Elemental Analysis: C, 72.62; H, 5.61; N, 10.16; O, 11.61
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 12.7 | 171.72 | |
| DMF | 20.0 | 48.37 | |
| DMF:PBS (pH 7.2) (1:2) | 0.3 | 0.60 |
The following data is based on the product molecular weight 413.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
