MedKoo Cat#: 465994 | Name: Miro1 Reducer 3

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Miro1 Reducer 3 is a novel degrader of Miro1 (mitochondrial Rho GTPase 1), reducing Miro1 levels in fibroblasts and stress-induced degeneration of dopaminergic neurons derived from Parkinson's disease (PD) patients, as well as age-dependent neuronal loss and prolongs lifespan in fly PD model.

Chemical Structure

Miro1 Reducer 3
Miro1 Reducer 3
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465994

Name: Miro1 Reducer 3

CAS#: unknown

Chemical Formula: C20H16FN7O

Exact Mass: 389.1400

Molecular Weight: 389.39

Elemental Analysis: C, 61.69; H, 4.14; F, 4.88; N, 25.18; O, 4.11

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Miro1 Reducer 3; Miro1 Reducer;
IUPAC/Chemical Name
1-(4-((6-(1H-imidazol-1-yl)pyrimidin-4-yl)amino)phenyl)-3-(3-fluorophenyl)urea
InChi Key
NXSISVIQOVDBCO-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H16FN7O/c21-14-2-1-3-17(10-14)27-20(29)26-16-6-4-15(5-7-16)25-18-11-19(24-12-23-18)28-9-8-22-13-28/h1-13H,(H,23,24,25)(H2,26,27,29)
SMILES Code
O=C(NC1=CC=C(NC2=NC=NC(N3C=CN=C3)=C2)C=C1)NC4=CC=CC(F)=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 389.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li L, Conradson DM, Bharat V, Kim MJ, Hsieh CH, Minhas PS, Papakyrikos AM, Durairaj AS, Ludlam A, Andreasson KI, Partridge L, Cianfrocco MA, Wang X. A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation. Nat Metab. 2021 Sep;3(9):1242-1258. doi: 10.1038/s42255-021-00443-2. Epub 2021 Sep 9. PMID: 34504353; PMCID: PMC8460615.