BC1464 | CAS#unknown | FBXO7/PINK1 interaction antagonist

MedKoo Cat#: 465993 | Name: BC1464

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BC1464 is a novel FBXO7/PINK1 interaction antagonist, abrogating FBXO7 and PINK1 association, leading to increased cellular PINK1 concentrations and activities, and limiting mitochondrial damage.

Chemical Structure

BC1464

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465993

Name: BC1464

CAS#: unknown

Chemical Formula: C26H30N4O4S

Exact Mass: 494.1988

Molecular Weight: 494.61

Elemental Analysis: C, 63.14; H, 6.11; N, 11.33; O, 12.94; S, 6.48

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

BC1464; BC 1464; BC-1464;

IUPAC/Chemical Name

N-benzyl-4-(4-oxo-2-((2-oxo-2-(((tetrahydrofuran-2-yl)methyl)amino)ethyl)thio)quinazolin-3(4H)-yl)butanamide

InChi Key

KAGVUCBIIIEDGM-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H30N4O4S/c31-23(27-16-19-8-2-1-3-9-19)13-6-14-30-25(33)21-11-4-5-12-22(21)29-26(30)35-18-24(32)28-17-20-10-7-15-34-20/h1-5,8-9,11-12,20H,6-7,10,13-18H2,(H,27,31)(H,28,32)

SMILES Code

O=C(NCC1=CC=CC=C1)CCCN2C(SCC(NCC3OCCC3)=O)=NC4=C(C=CC=C4)C2=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 494.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Liu Y, Lear TB, Verma M, Wang KZ, Otero PA, McKelvey AC, Dunn SR, Steer E, Bateman NW, Wu C, Jiang Y, Weathington NM, Rojas M, Chu CT, Chen BB, Mallampalli RK. Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1. JCI Insight. 2020 Jun 4;5(11):e131834. doi: 10.1172/jci.insight.131834. PMID: 32493843; PMCID: PMC7308049.