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MedKoo Cat#: 465989 | Name: TCMDC-136230

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TCMDC-136230 is a novel disruptor of the malaria parasite calcium dynamics, potently inducing calcium redistribution but minimally inhibiting heme crystallization.

Chemical Structure

TCMDC-136230
TCMDC-136230
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465989

Name: TCMDC-136230

CAS#: unknown

Chemical Formula: C24H34N4O2S

Exact Mass: 442.2402

Molecular Weight: 442.62

Elemental Analysis: C, 65.13; H, 7.74; N, 12.66; O, 7.23; S, 7.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
TCMDC-136230; TCMDC136230; TCMDC 136230;
IUPAC/Chemical Name
N-(sec-butyl)-1-(3,3-dimethylbutan-2-yl)-2-(p-tolylamino)-1H-benzo[d]imidazole-6-sulfonamide
InChi Key
APWADVQLCPBBJV-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H34N4O2S/c1-8-17(3)27-31(29,30)20-13-14-21-22(15-20)28(18(4)24(5,6)7)23(26-21)25-19-11-9-16(2)10-12-19/h9-15,17-18,27H,8H2,1-7H3,(H,25,26)
SMILES Code
O=S(C1=CC=C2C(N(C(C(C)(C)C)C)C(NC3=CC=C(C)C=C3)=N2)=C1)(NC(C)CC)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 442.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chia W, Gomez-Lorenzo MG, Castellote I, Tong JX, Chandramohanadas R, Thu Chu TT, Shen W, Go ML, de Cozar C, Crespo B, Almela MJ, Neria-Serrano F, Franco V, Gamo FJ, Tan KSW. High-Content Phenotypic Screen of a Focused TCAMS Drug Library Identifies Novel Disruptors of the Malaria Parasite Calcium Dynamics. ACS Chem Biol. 2021 Nov 19;16(11):2348-2372. doi: 10.1021/acschembio.1c00512. Epub 2021 Oct 5. PMID: 34609851.