MedKoo Cat#: 465987 | Name: PBENZ-DBRMD

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PBENZ-DBRMD is a first-in-class iodothyronine deiodinase type 3 (DIO3) inhibitor, demonstratig attenuated cell counts, induction in apoptosis, and a reduction in cell proliferation in DIO3-positive HGSOC cells (OVCAR3 and KURAMOCHI).

Chemical Structure

PBENZ-DBRMD
PBENZ-DBRMD
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465987

Name: PBENZ-DBRMD

CAS#: unknown

Chemical Formula: C11H5Br2NO4

Exact Mass: 372.8585

Molecular Weight: 374.97

Elemental Analysis: C, 35.23; H, 1.34; Br, 42.62; N, 3.74; O, 17.07

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PBENZ-DBRMD; PBENZ DBRMD; PBENZDBRMD;
IUPAC/Chemical Name
4-(3,4-dibromo-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid
InChi Key
HNIHLGFMEFERQO-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H5Br2NO4/c12-7-8(13)10(16)14(9(7)15)6-3-1-5(2-4-6)11(17)18/h1-4H,(H,17,18)
SMILES Code
O=C(O)C1=CC=C(N2C(C(Br)=C(Br)C2=O)=O)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 374.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Moskovich D, Finkelshtein Y, Alfandari A, Rosemarin A, Lifschytz T, Weisz A, Mondal S, Ungati H, Katzav A, Kidron D, Mugesh G, Ellis M, Lerer B, Ashur-Fabian O. Targeting the DIO3 enzyme using first-in-class inhibitors effectively suppresses tumor growth: a new paradigm in ovarian cancer treatment. Oncogene. 2021 Nov;40(44):6248-6257. doi: 10.1038/s41388-021-02020-z. Epub 2021 Sep 23. PMID: 34556811.