MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 465978 | Name: Phenylbutyrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Phenylbutyrate is a biochemical.

Chemical Structure

Phenylbutyrate
Phenylbutyrate
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465978

Name: Phenylbutyrate

CAS#: unknown

Chemical Formula: C11H14O

Exact Mass: 162.1045

Molecular Weight: 162.23

Elemental Analysis: C, 81.44; H, 8.70; O, 9.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Phenylbutyrate; Phenylbutyras; Fenilbutirato;
IUPAC/Chemical Name
5-phenylpentan-2-one
InChi Key
DGMYRPFYNFQCHM-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H14O/c1-10(12)6-5-9-11-7-3-2-4-8-11/h2-4,7-8H,5-6,9H2,1H3
SMILES Code
CC(CCCC1=CC=CC=C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 162.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yeo M, Rehsi P, Dorman M, Grunewald S, Baruteau J, Chakrapani A, Footitt E, Prunty H, McSweeney M. Direct replacement of oral sodium benzoate with glycerol phenylbutyrate in children with urea cycle disorders. JIMD Rep. 2022 Feb 2;63(2):137-145. doi: 10.1002/jmd2.12274. PMID: 35281661; PMCID: PMC8898712. 2: Yang CY, Liu SH, Su CC, Fang KM, Yang TY, Liu JM, Chen YW, Chang KC, Chuang HL, Wu CT, Lee KI, Huang CF. Methylmercury Induces Mitochondria- and Endoplasmic Reticulum Stress-Dependent Pancreatic β-Cell Apoptosis via an Oxidative Stress- Mediated JNK Signaling Pathway. Int J Mol Sci. 2022 Mar 5;23(5):2858. doi: 10.3390/ijms23052858. PMID: 35270009; PMCID: PMC8910963. 3: Chen C, Zhang B, Xue J, Li Z, Dou S, Chen H, Wang Q, Qu M, Wang H, Zhang Y, Wan L, Zhou Q, Xie L. Pathogenic Role of Endoplasmic Reticulum Stress in Diabetic Corneal Endothelial Dysfunction. Invest Ophthalmol Vis Sci. 2022 Mar 2;63(3):4. doi: 10.1167/iovs.63.3.4. PMID: 35238867; PMCID: PMC8899864. 4: Sun Y, Bedlack R, Armon C, Beauchamp M, Bertorini T, Bowser R, Bromberg M, Caress J, Carter G, Crayle J, Cudkowicz ME, Glass JD, Jackson C, Lund I, Martin S, Paganoni S, Pattee G, Ratner D, Salmon K, Wicks P. ALSUntangled #64: butyrates. Amyotroph Lateral Scler Frontotemporal Degener. 2022 Feb 28:1-6. doi: 10.1080/21678421.2022.2045323. Epub ahead of print. PMID: 35225121. 5: Elpidorou M, Poulter JA, Szymanska K, Baron W, Junger K, Boldt K, Ueffing M, Green L, Livingston JH, Sheridan EG, Johnson CA. Missense mutation of MAL causes a rare leukodystrophy similar to Pelizaeus-Merzbacher disease. Eur J Hum Genet. 2022 Feb 25. doi: 10.1038/s41431-022-01050-9. Epub ahead of print. PMID: 35217805. 6: Yue LL, Du X. Thrombospondin 1 Promotes Endoplasmic Reticulum Stress and Apoptosis in HK-2 Cells by Upregulating ATF6-CHOP. Curr Med Sci. 2022 Feb 22. doi: 10.1007/s11596-022-2513-8. Epub ahead of print. PMID: 35192143. 7: Xu L, Xie H, Hu S, Zhao X, Han M, Liu Q, Feng P, Wang W, Li C. HDAC3 inhibition improves urinary-concentrating defect in hypokalaemia by promoting AQP2 transcription. Acta Physiol (Oxf). 2022 Feb 18:e13802. doi: 10.1111/apha.13802. Epub ahead of print. PMID: 35178888. 8: Li Y, Jiang Y, Zhou W, Wu Y, Zhang S, Ding G, Zhang Y, Zhang A, Huang S, Jia Z, You R. Maintaining homeostasis of mitochondria and endoplasmic reticulum with NSC228155 alleviates cisplatin-induced acute kidney injury. Free Radic Biol Med. 2022 Mar;181:270-287. doi: 10.1016/j.freeradbiomed.2022.02.003. Epub 2022 Feb 5. PMID: 35134531. 9: Wang B, Zhang J, Liu X, Chai Q, Lu X, Yao X, Yang Z, Sun L, Johnson SF, Schwartz RC, Zheng YH. Protein disulfide isomerases (PDIs) negatively regulate ebolavirus structural glycoprotein expression in the endoplasmic reticulum (ER) via the autophagy-lysosomal pathway. Autophagy. 2022 Feb 7:1-18. doi: 10.1080/15548627.2022.2031381. Epub ahead of print. PMID: 35130104. 10: Frontiers Production Office. Erratum: Synergetic Effect of 4-Phenylbutyric Acid in Combination With Cyclosporine A on Cardiovascular Function in Sepsis Rats via Inhibition of Endoplasmic Reticulum Stress and Mitochondrial Permeability Transition Pore Opening. Front Pharmacol. 2022 Jan 18;12:845186. doi: 10.3389/fphar.2021.845186. Erratum for: Front Pharmacol. 2021 Nov 30;12:770558. PMID: 35115951; PMCID: PMC8805112. 11: Sha YG, Wang CL, Du ZW, Zheng BX, Zhou W, Zhao F, Ding GX, Zhang A. [Functional characterization of SLC12A1 gene variants in 3 patients with Bartter syndrome type Ⅰ]. Zhonghua Er Ke Za Zhi. 2022 Feb 2;60(2):129-133. Chinese. doi: 10.3760/cma.j.cn112140-20210603-00481. PMID: 35090230. 12: Ellis M, Ladiges W, Jiang Z. Physical performance is enhanced in old mice fed a short term diet medicated with rapamycin, acarbose, and phenylbutyrate. Aging Pathobiol Ther. 2021 Mar 29;3(1):12-13. doi: 10.31491/apt.2021.03.051. PMID: 35083452; PMCID: PMC8789187. 13: Liao J, Hu Z, Li Q, Li H, Chen W, Huo H, Han Q, Zhang H, Guo J, Hu L, Pan J, Li Y, Tang Z. Endoplasmic Reticulum Stress Contributes to Copper-Induced Pyroptosis via Regulating the IRE1α-XBP1 Pathway in Pig Jejunal Epithelial Cells. J Agric Food Chem. 2022 Feb 2;70(4):1293-1303. doi: 10.1021/acs.jafc.1c07927. Epub 2022 Jan 25. PMID: 35075900. 14: Yeom H, Hwang SH, Kim HG, Lee M. Increase in the sensitivity to PLX4720 through inhibition of transcription factor EB-dependent autophagy in BRAF inhibitor-resistant cells. Toxicol Res. 2021 Oct 11;38(1):35-44. doi: 10.1007/s43188-021-00109-x. PMID: 35070939; PMCID: PMC8748576. 15: Wu GB, Du HB, Zhai JY, Sun S, Cui JL, Zhang Y, Zhao ZA, Wu JL, Johnson AK, Xue B, Zhao ZG, Zhang GS. Controlled Hemorrhage Sensitizes Angiotensin II- Elicited Hypertension through Activation of the Brain Renin-Angiotensin System Independently of Endoplasmic Reticulum Stress. Oxid Med Cell Longev. 2022 Jan 13;2022:6371048. doi: 10.1155/2022/6371048. PMID: 35069977; PMCID: PMC8776443. 16: Wang X, Zhang Y, Wuyun K, Gong H. Therapeutic effect and mechanism of 4-phenyl butyric acid on renal ischemia-reperfusion injury in mice. Exp Ther Med. 2022 Feb;23(2):144. doi: 10.3892/etm.2021.11067. Epub 2021 Dec 15. PMID: 35069825; PMCID: PMC8756420. 17: Sicking M, Živná M, Bhadra P, Barešová V, Tirincsi A, Hadzibeganovic D, Hodaňová K, Vyleťal P, Sovová J, Jedličková I, Jung M, Bell T, Helms V, Bleyer AJ, Kmoch S, Cavalié A, Lang S. Phenylbutyrate rescues the transport defect of the Sec61α mutations V67G and T185A for renin. Life Sci Alliance. 2022 Jan 21;5(4):e202101150. doi: 10.26508/lsa.202101150. PMID: 35064074; PMCID: PMC8807872. 18: Rubio C, Avendaño-Ortiz J, Ruiz-Palomares R, Karaivanova V, Alberquilla O, Sánchez-Domínguez R, Casalvilla-Dueñas JC, Montalbán-Hernández K, Lodewijk I, Rodríguez-Izquierdo M, Munera-Maravilla E, Nunes SP, Suárez-Cabrera C, Pérez- Crespo M, Martínez VG, Morales L, Pérez-Escavy M, Alonso-Sánchez M, Lozano- Rodríguez R, Cueto FJ, Aguirre LA, Guerrero-Ramos F, Paramio JM, López-Collazo E, Dueñas M. Toward Tumor Fight and Tumor Microenvironment Remodeling: PBA Induces Cell Cycle Arrest and Reduces Tumor Hybrid Cells' Pluripotency in Bladder Cancer. Cancers (Basel). 2022 Jan 7;14(2):287. doi: 10.3390/cancers14020287. PMID: 35053451; PMCID: PMC8773853. 19: Chen J, Wu H, Tang X, Chen L. 4-Phenylbutyrate protects against rifampin- induced liver injury via regulating MRP2 ubiquitination through inhibiting endoplasmic reticulum stress. Bioengineered. 2022 Feb;13(2):2866-2877. doi: 10.1080/21655979.2021.2024970. PMID: 35045794. 20: Chen Q, Thompson J, Hu Y, Lesnefsky EJ. Reversing mitochondrial defects in aged hearts: role of mitochondrial calpain activation. Am J Physiol Cell Physiol. 2022 Feb 1;322(2):C296-C310. doi: 10.1152/ajpcell.00279.2021. Epub 2022 Jan 19. PMID: 35044856; PMCID: PMC8836732.