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MedKoo Cat#: 465943 | Name: COR1-25

Description:

WARNING: This product is for research use only, not for human or veterinary use.

COR1-25 is a novel potent and selective melanocortin-4 receptor inhibitor, possessing 15-fold selectivity for the MC4R versus the MC3R.

Chemical Structure

COR1-25
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465943

Name: COR1-25

CAS#: unknown

Chemical Formula: C36H48IN11O5

Exact Mass: 841.2885

Molecular Weight: 841.76

Elemental Analysis: C, 51.37; H, 5.75; I, 15.08; N, 18.30; O, 9.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
COR1-25; COR125; COR1 25;
IUPAC/Chemical Name
(S)-2-((R)-2-acetamido-3-(4-iodophenyl)propanamido)-N-((S)-1-(((S)-1-amino-5-guanidino-1-oxopentan-2-yl)amino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)-5-guanidinopentanamide
InChi Key
JFVISPBLQYTSHU-ZXYZSCNASA-N
InChi Code
InChI=1S/C36H48IN11O5/c1-21(49)45-29(19-22-11-14-26(37)15-12-22)33(52)47-28(9-5-17-44-36(41)42)32(51)48-30(20-23-10-13-24-6-2-3-7-25(24)18-23)34(53)46-27(31(38)50)8-4-16-43-35(39)40/h2-3,6-7,10-15,18,27-30H,4-5,8-9,16-17,19-20H2,1H3,(H2,38,50)(H,45,49)(H,46,53)(H,47,52)(H,48,51)(H4,39,40,43)(H4,41,42,44)/t27-,28-,29+,30-/m0/s1
SMILES Code
IC1=CC=C(C[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)CC2=CC(C=CC=C3)=C3C=C2)=O)CCCNC(N)=N)=O)NC(C)=O)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 841.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ericson MD, Doering SR, Larson CM, Freeman KT, LaVoi TM, Donow HM, Santos RG, Cho RH, Koerperich ZM, Giulianotti MA, Pinilla C, Houghten RA, Haskell-Luevano C. Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist. J Med Chem. 2021 Oct 14;64(19):14860-14875. doi: 10.1021/acs.jmedchem.1c01417. Epub 2021 Sep 30. PMID: 34592820; PMCID: PMC8533642.