IXA4 is a highly selective, non-toxic IRE1/XBP1s activator. IXA4 transiently activates protective IRE1/XBP1s signaling in liver without inducing RIDD or TRAF2/JNK signaling. IXA4 treatment improves systemic glucose metabolism and liver insulin action through IRE1-dependent remodeling of the hepatic transcriptome that reduces glucose production and steatosis. IXA4-stimulated IRE1 activation also enhances pancreatic function. Our findings indicate that systemic, transient activation of IRE1/XBP1s signaling engenders multi-tissue benefits that integrate to mitigate obesity-driven metabolic dysfunction.
MedKoo Cat#: 556064
Name: IXA4
CAS#: 1185329-96-7
Chemical Formula: C24H28N4O4
Exact Mass: 436.2111
Molecular Weight: 436.51
Elemental Analysis: C, 66.04; H, 6.47; N, 12.84; O, 14.66
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| dmso | 93.5 | 214.20 | |
| Ethanol | 11.0 | 25.20 |
The following data is based on the product molecular weight 436.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
