7-HCAA | CAS#905442-42-4 | Fluorescent amino acid

MedKoo Cat#: 465923 | Name: 7-HCAA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

7-HCAA is a fluorescent amino acid for protein labeling.

Chemical Structure

7-HCAA

CAS#905442-42-4

Theoretical Analysis

MedKoo Cat#: 465923

Name: 7-HCAA

CAS#: 905442-42-4

Chemical Formula: C13H13NO5

Exact Mass: 263.0794

Molecular Weight: 263.25

Elemental Analysis: C, 59.31; H, 4.98; N, 5.32; O, 30.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

7-HCAA; 7HCAA; 7 HCAA;

IUPAC/Chemical Name

(S)-2-amino-4-(7-hydroxy-2-oxo-2H-chromen-4-yl)butanoic acid

InChi Key

QEQAKQQRJFWPOR-JTQLQIEISA-N

InChi Code

InChI=1S/C13H13NO5/c14-10(13(17)18)4-1-7-5-12(16)19-11-6-8(15)2-3-9(7)11/h2-3,5-6,10,15H,1,4,14H2,(H,17,18)/t10-/m0/s1

SMILES Code

OC(C=C1)=CC2=C1C(CC[C@H](N)C(O)=O)=CC(O2)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 263.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Henderson JN, Simmons CR, Mills JH. Structural Basis for Blocked Excited State Proton Transfer in a Fluorescent, Photoacidic Non-Canonical Amino Acid- Containing Antibody Fragment. J Mol Biol. 2022 Jan 13:167455. doi: 10.1016/j.jmb.2022.167455. Epub ahead of print. PMID: 35033559. 2: Gleason PR, Kolbaba-Kartchner B, Henderson JN, Stahl EP, Simmons CR, Mills JH. Structural Origins of Altered Spectroscopic Properties upon Ligand Binding in Proteins Containing a Fluorescent Noncanonical Amino Acid. Biochemistry. 2021 Aug 31;60(34):2577-2585. doi: 10.1021/acs.biochem.1c00291. Epub 2021 Aug 20. PMID: 34415744; PMCID: PMC8879415. 3: Henderson JN, Simmons CR, Fahmi NE, Jeffs JW, Borges CR, Mills JH. Structural Insights into How Protein Environments Tune the Spectroscopic Properties of a Noncanonical Amino Acid Fluorophore. Biochemistry. 2020 Sep 22;59(37):3401-3410. doi: 10.1021/acs.biochem.0c00474. Epub 2020 Sep 3. PMID: 32845612; PMCID: PMC7964926. 4: Gleason PR, Kelly PI, Grisingher DW, Mills JH. An intrinsic FRET sensor of protein-ligand interactions. Org Biomol Chem. 2020 Jun 7;18(21):4079-4084. doi: 10.1039/d0ob00793e. Epub 2020 May 19. PMID: 32427252; PMCID: PMC7313717.