MedKoo Cat#: 465910 | Name: Homer
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Homer is the first potent and selective degrader probe for the WDR5 protein with a KD (ITC) of 18 nM.

Chemical Structure

Homer
Homer
CAS#2737222-94-3

Theoretical Analysis

MedKoo Cat#: 465910

Name: Homer

CAS#: 2737222-94-3

Chemical Formula: C52H60F3N9O7S

Exact Mass: 1011.4289

Molecular Weight: 1012.16

Elemental Analysis: C, 61.71; H, 5.98; F, 5.63; N, 12.45; O, 11.06; S, 3.17

Price and Availability

Size Price Availability Quantity
1mg USD 300.00 2 Weeks
5mg USD 650.00 2 Weeks
10mg USD 950.00 2 Weeks
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Related CAS #
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Synonym
Homer;
IUPAC/Chemical Name
N-(4'-((5-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-5-oxopentyl)carbamoyl)-4-(4-methylpiperazin-1-yl)-[1,1'-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
InChi Key
OFNZESNEBSQKSE-BQGOKDIQSA-N
InChi Code
InChI=1S/C52H60F3N9O7S/c1-31-45(72-30-59-31)34-11-9-32(10-12-34)27-58-49(70)42-25-37(65)29-64(42)50(71)46(51(2,3)4)61-43(66)8-6-7-19-56-47(68)35-15-13-33(14-16-35)36-17-18-41(63-22-20-62(5)21-23-63)40(24-36)60-48(69)38-28-57-44(67)26-39(38)52(53,54)55/h9-18,24,26,28,30,37,42,46,65H,6-8,19-23,25,27,29H2,1-5H3,(H,56,68)(H,57,67)(H,58,70)(H,60,69)(H,61,66)/t37-,42+,46-/m1/s1
SMILES Code
O=C(C(C(C(F)(F)F)=C1)=CNC1=O)NC2=CC(C3=CC=C(C(NCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)C=C3)=CC=C2N7CCN(C)CC7
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,012.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL