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MedKoo Cat#: 465908 | Name: Aβ31–35

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aβ31–35 is an Aβ Fragment, Decreasing Neprilysin-Mediated Alzheimer’s Amyloid-β Peptide Degradation.

Chemical Structure

Aβ31–35
Aβ31–35
CAS#149385-65-9

Theoretical Analysis

MedKoo Cat#: 465908

Name: Aβ31–35

CAS#: 149385-65-9

Chemical Formula: C25H47N5O6S

Exact Mass: 545.3247

Molecular Weight: 545.74

Elemental Analysis: C, 55.02; H, 8.68; N, 12.83; O, 17.59; S, 5.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Aβ31–35; Aβ3135; Aβ31 35; Aβ(31–35); Aβ(3135); Aβ(31 35); Amyloid-β (31-35); Amyloid β (31-35); Amyloid ß-Protein (31-35);
IUPAC/Chemical Name
L-isoleucyl-D-isoleucylglycyl-L-leucyl-L-methionine
InChi Key
ZMDGLWRNBGRYQB-XRFJLBFOSA-N
InChi Code
InChI=1S/C25H47N5O6S/c1-8-15(5)20(26)23(33)30-21(16(6)9-2)24(34)27-13-19(31)28-18(12-14(3)4)22(32)29-17(25(35)36)10-11-37-7/h14-18,20-21H,8-13,26H2,1-7H3,(H,27,34)(H,28,31)(H,29,32)(H,30,33)(H,35,36)/t15-,16+,17-,18-,20-,21+/m0/s1
SMILES Code
O=C(N[C@H]([C@H](C)CC)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(O)=O)=O)=O)=O)[C@H]([C@@H](C)CC)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 545.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yuan Y, Li C, Guo S, Sun C, Ning N, Hao H, Wang L, Bian Y, Liu H, Wang X. Adiponectin improves amyloid-β 31-35-induced circadian rhythm disorder in mice. J Cell Mol Med. 2021 Oct;25(20):9851-9862. doi: 10.1111/jcmm.16932. Epub 2021 Sep 15. PMID: 34523794; PMCID: PMC8505833. 2: Wang L, Zhao J, Wang CT, Hou XH, Ning N, Sun C, Guo S, Yuan Y, Li L, Hölscher C, Wang XH. D-Ser2-oxyntomodulin ameliorated Aβ31-35-induced circadian rhythm disorder in mice. CNS Neurosci Ther. 2020 Mar;26(3):343-354. doi: 10.1111/cns.13211. Epub 2019 Aug 14. PMID: 31411808; PMCID: PMC7053239. 3: Wang L, Zhang R, Hou X, Wang C, Guo S, Ning N, Sun C, Yuan Y, Li L, Hölscher C, Wang X. DA-JC1 improves learning and memory by antagonizing Aβ31-35-induced circadian rhythm disorder. Mol Brain. 2019 Feb 11;12(1):14. doi: 10.1186/s13041-019-0432-9. PMID: 30744651; PMCID: PMC6371467. 4: Hu M, Zhang J, Yang J, Cao Y, Qi J. A Novel scFv Anti-Aβ Antibody Reduces Pathological Impairments in APP/PS1 Transgenic Mice via Modulation of Inflammatory Cytokines and Aβ-related Enzymes. J Mol Neurosci. 2018 Sep;66(1):1-9. doi: 10.1007/s12031-018-1139-6. Epub 2018 Jul 31. PMID: 30062438. 5: Li T, Yuan L, Zhang J, Jiao JJ, Qi JS. [Real-time measurement of Ca2+ flux in hippocampal slice with non-invasive micro-test technique]. Sheng Li Xue Bao. 2017 Aug 25;69(4):467-476. Chinese. PMID: 28825106. 6: Cheng L, Zhang J, Li XY, Yuan L, Pan YF, Chen XR, Gao TM, Qiao JT, Qi JS. A novel antibody targeting sequence 31-35 in amyloid β protein attenuates Alzheimer's disease-related neuronal damage. Hippocampus. 2017 Feb;27(2):122-133. doi: 10.1002/hipo.22676. Epub 2016 Nov 8. PMID: 27784133. 7: Yuan L, Liu XJ, Han WN, Li QS, Wang ZJ, Wu MN, Yang W, Qi JS. [Gly14]-Humanin Protects Against Amyloid β Peptide-Induced Impairment of Spatial Learning and Memory in Rats. Neurosci Bull. 2016 Aug;32(4):374-82. doi: 10.1007/s12264-016-0041-x. Epub 2016 Jun 15. PMID: 27306655; PMCID: PMC5563781. 8: Wang X, Wang L, Yu Q, Xu Y, Zhang L, Zhao X, Cao X, Li Y, Li L. Alterations in the expression of Per1 and Per2 induced by Aβ31-35 in the suprachiasmatic nucleus, hippocampus, and heart of C57BL/6 mouse. Brain Res. 2016 Jul 1;1642:51-58. doi: 10.1016/j.brainres.2016.03.026. Epub 2016 Mar 25. PMID: 27021954. 9: Wang X, Wang L, Xu Y, Yu Q, Li L, Guo Y. Intranasal administration of Exendin-4 antagonizes Aβ31-35-induced disruption of circadian rhythm and impairment of learning and memory. Aging Clin Exp Res. 2016 Dec;28(6):1259-1266. doi: 10.1007/s40520-016-0548-z. Epub 2016 Feb 26. PMID: 26920423. 10: Zhang Y, Shi ZG, Wang ZH, Li JG, Chen JY, Zhang C. Effects of amyloid β-peptide fragment 31-35 on the BK channel-mediated K⁺ current and intracellular free Ca²⁺ concentration of hippocampal CA1 neurons. Neurosci Lett. 2014 May 7;568:72-6. doi: 10.1016/j.neulet.2014.03.028. Epub 2014 Mar 27. PMID: 24680749. 11: Wang ZJ, Han WN, Yang GZ, Yuan L, Liu XJ, Li QS, Qi JS. The neuroprotection of Rattin against amyloid β peptide in spatial memory and synaptic plasticity of rats. Hippocampus. 2014 Jan;24(1):44-53. doi: 10.1002/hipo.22202. Epub 2013 Sep 30. PMID: 23996574. 12: Liu XJ, Yuan L, Yang D, Han WN, Li QS, Yang W, Liu QS, Qi JS. Melatonin protects against amyloid-β-induced impairments of hippocampal LTP and spatial learning in rats. Synapse. 2013 Sep;67(9):626-36. doi: 10.1002/syn.21677. Epub 2013 May 27. PMID: 23620224. 13: Yuan L, Han WN, Li SF, Liu XJ, Wu MN, Qi JS. [[Gly14]-humanin protects against Aβ₃₁₋₃₅-induced impairment of spatial learning and memory in rats]. Sheng Li Xue Bao. 2012 Dec 25;64(6):625-32. Chinese. PMID: 23258324. 14: He YX, Wu MN, Zhang H, Qi JS. Amyloid β-protein suppressed nicotinic acetylcholine receptor-mediated currents in acutely isolated rat hippocampal CA1 pyramidal neurons. Synapse. 2013 Jan;67(1):11-20. doi: 10.1002/syn.21611. Epub 2012 Oct 16. PMID: 23015319. 15: Li SF, Wu MN, Wang XH, Yuan L, Yang D, Qi JS. Requirement of α7 nicotinic acetylcholine receptors for amyloid β protein-induced depression of hippocampal long-term potentiation in CA1 region of rats in vivo. Synapse. 2011 Nov;65(11):1136-43. doi: 10.1002/syn.20951. Epub 2011 Jun 10. PMID: 21584864. 16: Ding B, Yuan L, Yu H, Li L, Ma W, Bi Y, Feng J, Xiao R. Genistein and folic acid prevent oxidative injury induced by β-amyloid peptide. Basic Clin Pharmacol Toxicol. 2011 May;108(5):333-40. doi: 10.1111/j.1742-7843.2010.00661.x. Epub 2011 Jan 11. PMID: 21205217. 17: Yu HL, Zhang XH, Xiao R, Li L, Xiang L, Feng JF, Yuan LH, Ma WW. [Effects of genistein and folic acid on neuronal membrane and mitochondrial membrane damaged by β-amyloid peptides 31-35]. Zhonghua Yu Fang Yi Xue Za Zhi. 2010 Jul;44(7):607-11. Chinese. PMID: 21055075. 18: Li LM, Zhang Y, Qiao JT, Zhang C. Humanin protects neurons against apoptosis induced by Abeta31-35 through suppression of intrinsic pathway. Sheng Li Xue Bao. 2010 Apr 25;62(2):93-100. PMID: 20401442. 19: Zhang XH, Yu HL, Xiao R, Xiang L, Li L, Ma WW, Zhang J, Chu JH. [Neurotoxicity of beta-amyloid peptide 31-35 and 25-35 to cultured rat cortical neurons]. Zhonghua Yu Fang Yi Xue Za Zhi. 2009 Dec;43(12):1081-5. Chinese. PMID: 20193504. 20: Li LM, Liu QH, Qiao JT, Zhang C. Abeta(31-35)-induced neuronal apoptosis is mediated by JNK-dependent extrinsic apoptosis pathway. Neurosci Bull. 2009 Dec;25(6):361-6. doi: 10.1007/s12264-009-0629-5. PMID: 19927172; PMCID: PMC5552508.

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