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MedKoo Cat#: 465881 | Name: 7-OH-Neo A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

7-OH-Neo A is a natural hypoxia-inducible factor-1α (HIF-1α) inhibitor, targeting the protein activity which could stabilize HIF-1α.

Chemical Structure

7-OH-Neo A
7-OH-Neo A
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465881

Name: 7-OH-Neo A

CAS#: unknown

Chemical Formula: C24H19NO5

Exact Mass: 401.1263

Molecular Weight: 401.42

Elemental Analysis: C, 71.81; H, 4.77; N, 3.49; O, 19.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
7-OH-Neo A; 7OHNeo A; 7 OH Neo A; 7OH-Neo A; 7 OH-Neo A; 7-OHNeo A; 7-OH Neo A; 7-Hydroxyneolamellarin A; 7 Hydroxyneolamellarin A;
IUPAC/Chemical Name
1-(3,4-bis(4-hydroxyphenyl)-1H-pyrrol-1-yl)-2-hydroxy-2-(4-hydroxyphenyl)ethan-1-one
InChi Key
RYIBSKICTMDCHH-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H19NO5/c26-18-7-1-15(2-8-18)21-13-25(14-22(21)16-3-9-19(27)10-4-16)24(30)23(29)17-5-11-20(28)12-6-17/h1-14,23,26-29H
SMILES Code
O=C(N1C=C(C2=CC=C(O)C=C2)C(C3=CC=C(O)C=C3)=C1)C(O)C4=CC=C(O)C=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 401.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li G, Shao Y, Pan Y, Li Y, Wang Y, Wang L, Wang X, Shao K, Wang S, Liu N, Zhang J, Zhao W, Nakamura H. Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy. Bioorg Med Chem Lett. 2021 Oct 15;50:128338. doi: 10.1016/j.bmcl.2021.128338. Epub 2021 Aug 29. PMID: 34469710. 2: Liu R, Liu Y, Zhou YD, Nagle DG. Molecular-targeted antitumor agents. 15. Neolamellarins from the marine sponge Dendrilla nigra inhibit hypoxia-inducible factor-1 activation and secreted vascular endothelial growth factor production in breast tumor cells. J Nat Prod. 2007 Nov;70(11):1741-5. doi: 10.1021/np070206e. Epub 2007 Oct 25. PMID: 17958397; PMCID: PMC2914556.