MedKoo Cat#: 465879 | Name: MNK8
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MNK8 is a novel inhibitor of STAT3 activation, reducing DNA binding ability, increasing SubG1 cell population and inducing apoptosis in HCC cells.

Chemical Structure

MNK8
CAS#2055078-49-2

Theoretical Analysis

MedKoo Cat#: 465879

Name: MNK8

CAS#: 2055078-49-2

Chemical Formula: C15H12N2O2

Exact Mass: 252.0899

Molecular Weight: 252.27

Elemental Analysis: C, 71.42; H, 4.79; N, 11.10; O, 12.68

Price and Availability

Size Price Availability Quantity
50mg USD 550.00 2 Weeks
100mg USD 950.00 2 Weeks
200mg USD 1,650.00 2 Weeks
500mg USD 2,950.00 2 Weeks
1g USD 4,250.00 2 Weeks
2g USD 6,850.00 2 Weeks
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Related CAS #
No Data
Synonym
MNK8; MNK 8; MNK-8;
IUPAC/Chemical Name
3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione
InChi Key
SJRMGNRXVMMJSY-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H12N2O2/c1-17-14(18)9-13(16-15(17)19)12-8-4-6-10-5-2-3-7-11(10)12/h2-9H,1H3,(H,16,19)
SMILES Code
O=C1N(C)C(C=C(C2=C3C=CC=CC3=CC=C2)N1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 252.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sajith AM, Narasimhamurthy KH, Shanmugam MK, Rangappa S, Chandra Nayak S, Chinnathambi A, Awad Alahmadi T, Ali Alharbi S, Haridas KR, Reddy EK, Savitha B, Mohan CD, Rangappa KS. Pyrimidine-2,4-dione targets STAT3 signaling pathway to induce cytotoxicity in hepatocellular carcinoma cells. Bioorg Med Chem Lett. 2021 Oct 15;50:128332. doi: 10.1016/j.bmcl.2021.128332. Epub 2021 Aug 19. PMID: 34418571.