Synonym
Levotensin; Moprolol hydrochloride; Moprolol HCl
IUPAC/Chemical Name
2-Propanol, 1-(2-methoxyphenoxy)-3-((1-methylethyl)amino)-, hydrochloride (9CI)
InChi Key
JKEZSJIWQWVVQR-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H21NO3.ClH/c1-10(2)14-8-11(15)9-17-13-7-5-4-6-12(13)16-3;/h4-7,10-11,14-15H,8-9H2,1-3H3;1H
SMILES Code
Cl.COc1ccccc1OCC(O)CNC(C)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
275.77
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Rossetti L, Barbieri P, Velati P, Bujtar E, Orzalesi N. The efficacy of the combination of l-moprolol and dipivefrin in reducing the intraocular pressure in primary open-angle glaucoma or in ocular hypertension. Graefes Arch Clin Exp Ophthalmol. 1994 Nov;232(11):670-4. PubMed PMID: 7843592.
2: Porciatti F, Cerbai E, Masini I, Mugelli A. Electrophysiological evaluation of the beta-blocking properties and direct membrane effects of l-moprolol and its enantiomer d-moprolol. Arch Int Pharmacodyn Ther. 1989 May-Jun;299:200-9. PubMed PMID: 2570555.
3: Ghosh S, Bhaumik J, Banoth L, Banesh S, Banerjee UC. Chemoenzymatic Route for the Synthesis of (S)-Moprolol, a Potential β-Blocker. Chirality. 2016 Apr;28(4):313-8. doi: 10.1002/chir.22574. Epub 2016 Jan 28. PubMed PMID: 26821612.
4: Li F, Bi H, Côté M, Cooper S. Identification and determination of the enantiomers of moprolol and their metabolites in human urine by high-performance liquid chromatography and gas chromatography-mass spectrometry. J Chromatogr. 1993 Dec 22;622(2):187-95. PubMed PMID: 7908669.
5: Triulzi MO, Balice G, Gentile F, Rossini GL, Fattori CM. Tolerability of high doses of (-)-moprolol in healthy volunteers. Eur J Clin Pharmacol. 1982;22(4):377-8. PubMed PMID: 6125397.