EL-0052 is a novel etomidate analogue, enhancing GABAA receptors currents with a concentration for 50% of maximal effect (EC50) of 0.98 {plus minus} 0.02 μM, which was about three times more potent than etomidate (3.07 {plus minus} 1.67 μM), retaining the favorable properties of etomidate, including potent hypnotic effect, rapid onset and recovery, stable hemodynamics and high therapeutic index without suppression of adrenocortical function.
MedKoo Cat#: 465872
Name: EL-0052
CAS#: unknown
Chemical Formula: C14H15FN2O2
Exact Mass: 262.1118
Molecular Weight: 262.28
Elemental Analysis: C, 64.11; H, 5.76; F, 7.24; N, 10.68; O, 12.20
The following data is based on the product molecular weight 262.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
