Synonym
PD 168568 dihydrochloride; PD168568. 2HCl; PD 168568. 2HCl; PD-168568. 2HCl
IUPAC/Chemical Name
3-(2-(4-(3,4-dimethylphenyl)piperazin-1-yl)ethyl)isoindolin-1-one dihydrochloride
InChi Key
RMNWLEGGYCVHFD-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H27N3O.2ClH/c1-16-7-8-18(15-17(16)2)25-13-11-24(12-14-25)10-9-21-19-5-3-4-6-20(19)22(26)23-21;;/h3-8,15,21H,9-14H2,1-2H3,(H,23,26);2*1H
SMILES Code
O=C1NC(CCN2CCN(CC2)C3=CC=C(C(C)=C3)C)C4=C1C=CC=C4.[H]Cl.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
422.39
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Günther, S., Reinke, P. Y., Fernández-García, Y., Lieske, J., Lane, T. J., Ginn, H. M., ... & Meents, A. (2021). X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease. Science, 372(6542), 642-646.
Dairaghi, L., Constantin, S., Oh, A., Shostak, D., & Wray, S. (2022). The dopamine D4 receptor regulates gonadotropin-releasing hormone neuron excitability in male mice. Eneuro, 9(2).
Dolma, S., Selvadurai, H. J., Lan, X., Lee, L., Kushida, M., Voisin, V., ... & Dirks, P. B. (2016). Inhibition of dopamine receptor D4 impedes autophagic flux, proliferation, and survival of glioblastoma stem cells. Cancer cell, 29(6), 859-873.
