(S)-(-)-MRJF22 | CAS#unknown | Antimigratory produrg enantiomer

MedKoo Cat#: 465851 | Name: (S)-(-)-MRJF22

Description:

WARNING: This product is for research use only, not for human or veterinary use.

(S)-(-)-MRJF22 is a more active enantiomer of the prodrug of the sigma (σ) ligand haloperidol metabolite II conjugated with the histone deacetylase (HDAC) inhibitor valproic acid, exhibiting the highest antimigratory effects in endothelial and tumor cells.

Chemical Structure

(S)-(-)-MRJF22

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465851

Name: (S)-(-)-MRJF22

CAS#: unknown

Chemical Formula: C29H39ClFNO3

Exact Mass: 503.2603

Molecular Weight: 504.08

Elemental Analysis: C, 69.10; H, 7.80; Cl, 7.03; F, 3.77; N, 2.78; O, 9.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

(S)-(-)-MRJF22; (S)(-)-MRJF22; (S) (-)-MRJF22; (S)-(-)MRJF22; (S)-(-) MRJF22; (S)(-)MRJF22; (S) (-) MRJF22;

IUPAC/Chemical Name

(R)-4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butyl 2-propylpentanoate

InChi Key

ZMMTZQWVQFDIBG-HHHXNRCGSA-N

InChi Code

InChI=1S/C29H39ClFNO3/c1-3-6-23(7-4-2)28(33)35-27(22-9-15-26(31)16-10-22)8-5-19-32-20-17-29(34,18-21-32)24-11-13-25(30)14-12-24/h9-16,23,27,34H,3-8,17-21H2,1-2H3/t27-/m1/s1

SMILES Code

CCCC(CCC)C(O[C@@H](C1=CC=C(F)C=C1)CCCN2CCC(O)(C3=CC=C(Cl)C=C3)CC2)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 504.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Barbaraci C, Giurdanella G, Leotta CG, Longo A, Amata E, Dichiara M, Pasquinucci L, Turnaturi R, Prezzavento O, Cacciatore I, Zuccarello E, Lupo G, Pitari GM, Anfuso CD, Marrazzo A. Haloperidol Metabolite II Valproate Ester (S)-(-)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma. J Med Chem. 2021 Sep 23;64(18):13622-13632. doi: 10.1021/acs.jmedchem.1c00995. Epub 2021 Sep 3. PMID: 34477381; PMCID: PMC8474110.