Synonym
CNS1261; CNS 1261; CNS-1261;
IUPAC/Chemical Name
3-(3-iodophenyl)-1-methyl-1-(naphthalen-1-yl)guanidine
InChi Key
RKXNYRXVRDRRPZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H16IN3/c1-22(18(20)21-15-9-5-8-14(19)12-15)17-11-4-7-13-6-2-3-10-16(13)17/h2-12H,1H3,(H2,20,21)
SMILES Code
N=C(NC1=CC=CC(I)=C1)N(C2=C3C=CC=CC3=CC=C2)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
401.25
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Naumiec GR, Cai L, Pike VW. New N-aryl-N'-(3-(substituted)phenyl)-N'-methylguanidines as leads to potential PET radioligands for imaging the open NMDA receptor. Bioorg Med Chem Lett. 2015 Jan 15;25(2):225-8. doi: 10.1016/j.bmcl.2014.11.066. Epub 2014 Nov 29. PMID: 25499436; PMCID: PMC4293695.
2: Stone JM. Imaging the glutamate system in humans: relevance to drug discovery for schizophrenia. Curr Pharm Des. 2009;15(22):2594-602. doi: 10.2174/138161209788957438. PMID: 19689330.
3: Knol RJ, de Bruin K, van Eck-Smit BL, Pimlott S, Wyper DJ, Booij J. In vivo [(123)I]CNS-1261 binding to D-serine-activated and MK801-blocked NMDA receptors: A storage phosphor imaging study in rats. Synapse. 2009 Jul;63(7):557-64. doi: 10.1002/syn.20629. PMID: 19288577.
4: Stone JM, Erlandsson K, Arstad E, Squassante L, Teneggi V, Bressan RA, Krystal JH, Ell PJ, Pilowsky LS. Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy: a [(123)I]CNS-1261 SPET study. Psychopharmacology (Berl). 2008 Apr;197(3):401-8. doi: 10.1007/s00213-007-1047-x. Epub 2008 Jan 5. PMID: 18176855.
5: Stone JM, Erlandsson K, Arstad E, Bressan RA, Squassante L, Teneggi V, Ell PJ, Pilowsky LS. Ketamine displaces the novel NMDA receptor SPET probe [(123)I]CNS-1261 in humans in vivo. Nucl Med Biol. 2006 Feb;33(2):239-43. doi: 10.1016/j.nucmedbio.2005.12.001. PMID: 16546678.
6: Bressan RA, Erlandsson K, Stone JM, Mulligan RS, Krystal JH, Ell PJ, Pilowsky LS. Impact of schizophrenia and chronic antipsychotic treatment on [123I]CNS-1261 binding to N-methyl-D-aspartate receptors in vivo. Biol Psychiatry. 2005 Jul 1;58(1):41-6. doi: 10.1016/j.biopsych.2005.03.016. PMID: 15992521.
