MedKoo Cat#: 465841 | Name: ALX5406

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ALX5406 is a prodrug of ALX5407, a selective non-transportable inhibitor of the glycine transporter GlyT1.

Chemical Structure

ALX5406
ALX5406
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465841

Name: ALX5406

CAS#: unknown

Chemical Formula: C25H26FNO3

Exact Mass: 407.1897

Molecular Weight: 407.49

Elemental Analysis: C, 73.69; H, 6.43; F, 4.66; N, 3.44; O, 11.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ALX5406; ALX 5406; ALX-5406;
IUPAC/Chemical Name
methyl (R)-N-(3-([1,1'-biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl)-N-methylglycinate
InChi Key
ZOJAWWUHKCSKRU-XMMPIXPASA-N
InChi Code
InChI=1S/C25H26FNO3/c1-27(18-25(28)29-2)17-16-24(21-8-12-22(26)13-9-21)30-23-14-10-20(11-15-23)19-6-4-3-5-7-19/h3-15,24H,16-18H2,1-2H3/t24-/m1/s1
SMILES Code
O=C(OC)CN(CC[C@@H](OC1=CC=C(C2=CC=CC=C2)C=C1)C3=CC=C(F)C=C3)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 407.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hoffmann C, Evcüman S, Neumaier F, Zlatopolskiy BD, Humpert S, Bier D, Holschbach M, Schulze A, Endepols H, Neumaier B. [18F]ALX5406: A Brain-Penetrating Prodrug for GlyT1-Specific PET Imaging. ACS Chem Neurosci. 2021 Sep 15;12(18):3335-3346. doi: 10.1021/acschemneuro.1c00284. Epub 2021 Aug 27. PMID: 34449193.