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MedKoo Cat#: 465823 | Name: HM01

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HM01 is an acylated ghrelin receptor agonist that paradoxically exacerbates muscle wasting in aged mice. In the study, 24-month-old mice treated with HM01 for 4 weeks exhibited significant reductions in lean body mass and muscle strength, despite increased food intake and body weight. Specifically, HM01-treated mice showed decreased grip strength and reduced muscle fiber cross-sectional area, indicating muscle atrophy. Moreover, HM01 administration led to elevated oxidative stress markers, such as increased protein carbonylation and lipid peroxidation, alongside decreased expression of antioxidant enzymes like superoxide dismutase 2 (SOD2).

Chemical Structure

HM01
HM01
CAS#1394860-28-6

Theoretical Analysis

MedKoo Cat#: 465823

Name: HM01

CAS#: 1394860-28-6

Chemical Formula: C19H29Cl2N3O2

Exact Mass: 401.1637

Molecular Weight: 402.36

Elemental Analysis: C, 56.72; H, 7.27; Cl, 17.62; N, 10.44; O, 7.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
HM01; HM 01; HM-01;
IUPAC/Chemical Name
3-((S)-1-(2,3-dichloro-4-methoxyphenyl)ethyl)-1-methyl-1-(1,3,3-trimethylpiperidin-4-yl)urea
InChi Key
WGIAKIIMCPKJQN-SFVWDYPZSA-N
InChi Code
InChI=1S/C19H29Cl2N3O2/c1-12(13-7-8-14(26-6)17(21)16(13)20)22-18(25)24(5)15-9-10-23(4)11-19(15,2)3/h7-8,12,15H,9-11H2,1-6H3,(H,22,25)/t12-,15?/m0/s1
SMILES Code
CN(C(N[C@@H](C)C1=CC=C(OC)C(Cl)=C1Cl)=O)C2CCN(C)CC2(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 402.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chiorazzi A, Wozniak KM, Rais R, Wu Y, Gadiano AJ, Farah MH, Liu Y, Canta A, Alberti P, Rodriguez-Menendez V, Meregalli C, Fumagalli G, Monza L, Pozzi E, Vornov JJ, Polydefkis M, Pietra C, Slusher BS, Cavaletti G. Ghrelin agonist HM01 attenuates chemotherapy-induced neurotoxicity in rodent models. Eur J Pharmacol. 2018 Dec 5;840:89-103. doi: 10.1016/j.ejphar.2018.09.029. Epub 2018 Sep 27. PMID: 30268665. 2: Tu L, Lu Z, Ngan MP, Lam FFY, Giuliano C, Lovati E, Pietra C, Rudd JA. The brain-penetrating, orally bioavailable, ghrelin receptor agonist HM01 ameliorates motion-induced emesis in Suncus murinus (house musk shrew). Br J Pharmacol. 2020 Apr;177(7):1635-1650. doi: 10.1111/bph.14924. Epub 2020 Feb 3. PMID: 31722444; PMCID: PMC7060360. 3: Naitou K, Mamerto TP, Pustovit RV, Callaghan B, Rivera LR, Chan AJ, Ringuet MT, Pietra C, Furness JB. Site and mechanism of the colokinetic action of the ghrelin receptor agonist, HM01. Neurogastroenterol Motil. 2015 Dec;27(12):1764-71. doi: 10.1111/nmo.12688. Epub 2015 Sep 28. PMID: 26416336. 4: Howick K, Chruscicka B, Felice D, Ramirez VT, van Leuven L, Pietra C, Cryan JF, Griffin BT, Schellekens H. Behavioural characterization of ghrelin ligands, anamorelin and HM01: Appetite and reward-motivated effects in rodents. Neuropharmacology. 2020 May 15;168:108011. doi: 10.1016/j.neuropharm.2020.108011. Epub 2020 Feb 14. PMID: 32067989. 5: Minalyan A, Gabrielyan L, Pietra C, Taché Y, Wang L. Multiple Beneficial Effects of Ghrelin Agonist, HM01 on Homeostasis Alterations in 6-Hydroxydopamine Model of Parkinson's Disease in Male Rats. Front Integr Neurosci. 2019 Apr 12;13:13. doi: 10.3389/fnint.2019.00013. PMID: 31031602; PMCID: PMC6474391. 6: Karasawa H, Pietra C, Giuliano C, Garcia-Rubio S, Xu X, Yakabi S, Taché Y, Wang L. New ghrelin agonist, HM01 alleviates constipation and L-dopa-delayed gastric emptying in 6-hydroxydopamine rat model of Parkinson's disease. Neurogastroenterol Motil. 2014 Dec;26(12):1771-82. doi: 10.1111/nmo.12459. Epub 2014 Oct 19. PMID: 25327342; PMCID: PMC4457321. 7: Borner T, Loi L, Pietra C, Giuliano C, Lutz TA, Riediger T. The ghrelin receptor agonist HM01 mimics the neuronal effects of ghrelin in the arcuate nucleus and attenuates anorexia-cachexia syndrome in tumor-bearing rats. Am J Physiol Regul Integr Comp Physiol. 2016 Jul 1;311(1):R89-96. doi: 10.1152/ajpregu.00044.2016. Epub 2016 May 4. PMID: 27147616. 8: Rudd JA, Chan SW, Ngan MP, Tu L, Lu Z, Giuliano C, Lovati E, Pietra C. Anti- emetic Action of the Brain-Penetrating New Ghrelin Agonist, HM01, Alone and in Combination With the 5-HT3 Antagonist, Palonosetron and With the NK1 Antagonist, Netupitant, Against Cisplatin- and Motion-Induced Emesis in Suncus murinus (House Musk Shrew). Front Pharmacol. 2018 Aug 6;9:869. doi: 10.3389/fphar.2018.00869. Erratum in: Front Pharmacol. 2018 Sep 28;9:1102. PMID: 30127745; PMCID: PMC6087754. 9: Zhou R, Yang X, Li X, Qu Y, Huang Q, Sun X, Mu D. Recombinant CC16 inhibits NLRP3/caspase-1-induced pyroptosis through p38 MAPK and ERK signaling pathways in the brain of a neonatal rat model with sepsis. J Neuroinflammation. 2019 Nov 27;16(1):239. doi: 10.1186/s12974-019-1651-9. PMID: 31775794; PMCID: PMC6882041. 10: Villars FO, Pietra C, Giuliano C, Lutz TA, Riediger T. Oral Treatment with the Ghrelin Receptor Agonist HM01 Attenuates Cachexia in Mice Bearing Colon-26 (C26) Tumors. Int J Mol Sci. 2017 May 5;18(5):986. doi: 10.3390/ijms18050986. PMID: 28475119; PMCID: PMC5454899. 11: Mali H, Shah C, Rudakiya DM, Patel DH, Trivedi U, Subramanian RB. A novel organophosphate hydrolase from Arthrobacter sp. HM01: Characterization and applications. Bioresour Technol. 2022 Feb 19:126870. doi: 10.1016/j.biortech.2022.126870. Epub ahead of print. PMID: 35192947. 12: Zeng Q, Zhang L, Zhou Y. Advances in Selective Carbon-Heteroatom Coupling Reactions. Chem Rec. 2018 Sep;18(9):1278-1291. doi: 10.1002/tcr.201800028. Epub 2018 Jul 11. PMID: 29993177. 13: N Mohammadi E, Louwies T, Pietra C, Northrup SR, Greenwood-Van Meerveld B. Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics. J Exp Pharmacol. 2020 Aug 5;12:267-274. doi: 10.2147/JEP.S249747. PMID: 32801950; PMCID: PMC7415447. 14: Mohammadi EN, Pietra C, Giuliano C, Fugang L, Greenwood-Van Meerveld B. A Comparison of the Central versus Peripheral Gastrointestinal Prokinetic Activity of Two Novel Ghrelin Mimetics. J Pharmacol Exp Ther. 2019 Jan;368(1):116-124. doi: 10.1124/jpet.118.250738. Epub 2018 Oct 30. PMID: 30377215. 15: Rudd JA, Chan SW, Ngan MP, Tu L, Lu Z, Giuliano C, Lovati E, Pietra C. Corrigendum: Anti-emetic Action of the Brain-Penetrating New Ghrelin Agonist, HM01, Alone and in Combination With the 5-HT3 Antagonist, Palonosetron and With the NK1 Antagonist, Netupitant, Against Cisplatin- and Motion-Induced Emesis in Suncus murinus (House Musk Shrew). Front Pharmacol. 2018 Sep 28;9:1102. doi: 10.3389/fphar.2018.01102. Erratum for: Front Pharmacol. 2018 Aug 06;9:869. Lu, Zhengbing [corrected to Lu, Zengbing]. PMID: 30310382; PMCID: PMC6173214. 16: Zeng Y, Wang J, Huang Q, Ren Y, Li T, Zhang X, Yao R, Sun J. Cucurbitacin IIa: A review of phytochemistry and pharmacology. Phytother Res. 2021 Aug;35(8):4155-4170. doi: 10.1002/ptr.7077. Epub 2021 Mar 16. PMID: 33724593. 17: Shankar K, Gupta D, Mani BK, Findley BG, Lord CC, Osborne-Lawrence S, Metzger NP, Pietra C, Liu C, Berglund ED, Zigman JM. Acyl-ghrelin Is Permissive for the Normal Counterregulatory Response to Insulin-Induced Hypoglycemia. Diabetes. 2020 Feb;69(2):228-237. doi: 10.2337/db19-0438. Epub 2019 Nov 4. PMID: 31685528; PMCID: PMC6971486. 18: Xie L, Tang H, Song J, Long J, Zhang L, Li X. Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics. J Pharm Pharmacol. 2019 Oct;71(10):1475-1487. doi: 10.1111/jphp.13143. Epub 2019 Aug 1. PMID: 31373015. 19: Lou G, Wang J, Hu J, Gan Q, Peng C, Xiong H, Huang Q. Sanguinarine: A Double-Edged Sword of Anticancer and Carcinogenesis and Its Future Application Prospect. Anticancer Agents Med Chem. 2021 Oct 28;21(16):2100-2110. doi: 10.2174/1871520621666210126091512. PMID: 33573577. 20: Wang CS, Wang J, Zhang X, Zhang L, Zhang HP, Wang L, Wood LG, Wang G. Is the consumption of fast foods associated with asthma or other allergic diseases? Respirology. 2018 Oct;23(10):901-913. doi: 10.1111/resp.13339. Epub 2018 Jul 4. PMID: 29974559.