Z-505 | CAS#unknown | GHS-R1a ligand

MedKoo Cat#: 465822 | Name: Z-505

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Z-505 is a GHS-R1a ligand.

Chemical Structure

Z-505

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465822

Name: Z-505

CAS#: unknown

Chemical Formula: C28H37N5O4S

Exact Mass: 539.2566

Molecular Weight: 539.70

Elemental Analysis: C, 62.31; H, 6.91; N, 12.98; O, 11.86; S, 5.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Z-505; Z505; Z 505;

IUPAC/Chemical Name

(2R)-2-(2-amino-2-methylpropanamido)-4-methyl-N-(2-oxo-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-yl)pentanamide

InChi Key

WTPBPKNYMZWUEV-VQCQRNETSA-N

InChi Code

InChI=1S/C28H37N5O4S/c1-17(2)13-20(31-27(37)28(3,4)29)25(35)30-21-14-19-7-5-8-22(32-11-6-9-23(32)34)24(19)33(26(21)36)15-18-10-12-38-16-18/h5,7-8,10,12,16-17,20-21H,6,9,11,13-15,29H2,1-4H3,(H,30,35)(H,31,37)/t20-,21?/m1/s1

SMILES Code

O=C(CCC1)N1C2=C(N(CC3=CSC=C3)C(C(NC([C@H](NC(C(C)(N)C)=O)CC(C)C)=O)C4)=O)C4=CC=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 539.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Shiomi Y, Yoshimura M, Hori Y, Ohira Y, Nagahama K, Ozaki T, Takei M, Tanaka T, Uno T. Z-505, an Oral Ghrelin Receptor Agonist, Attenuates Anorexia After Total Gastrectomy in Rats. J Surg Res. 2020 Feb;246:527-534. doi: 10.1016/j.jss.2019.09.035. Epub 2019 Oct 25. PMID: 31668932. 2: Shiomi Y, Ohira Y, Yoshimura M, Ozaki T, Takei M, Tanaka T. Z-505 hydrochloride ameliorates chemotherapy-induced anorexia in rodents via activation of the ghrelin receptor, GHSR1a. Eur J Pharmacol. 2018 Jan 5;818:148-157. doi: 10.1016/j.ejphar.2017.10.047. Epub 2017 Oct 21. PMID: 29066414. 3: Yoshimura M, Shiomi Y, Ohira Y, Takei M, Tanaka T. Z-505 hydrochloride, an orally active ghrelin agonist, attenuates the progression of cancer cachexia via anabolic hormones in Colon 26 tumor-bearing mice. Eur J Pharmacol. 2017 Sep 15;811:30-37. doi: 10.1016/j.ejphar.2017.05.036. Epub 2017 May 18. PMID: 28529141.