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MedKoo Cat#: 465800 | Name: AM879

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AM879 is a potent and selective ATAD2 Inhibitor.

Chemical Structure

AM879
AM879
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465800

Name: AM879

CAS#: unknown

Chemical Formula: C24H15ClN4O3

Exact Mass: 442.0833

Molecular Weight: 442.86

Elemental Analysis: C, 65.09; H, 3.41; Cl, 8.00; N, 12.65; O, 10.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
AM879; AM 879; AM-879;
IUPAC/Chemical Name
(Z)-3-(5-((2-amino-3,7-dicyano-4,6-dimethyl-5H-cyclopenta[b]pyridin-5-ylidene)methyl)furan-2-yl)-4-chlorobenzoic acid
InChi Key
CKEZGFZETZHCNE-NVNXTCNLSA-N
InChi Code
InChI=1S/C24H15ClN4O3/c1-11-15(21-12(2)18(10-27)23(28)29-22(21)17(11)9-26)8-14-4-6-20(32-14)16-7-13(24(30)31)3-5-19(16)25/h3-8H,1-2H3,(H2,28,29)(H,30,31)/b15-8-
SMILES Code
ClC1=C(C2=CC=C(/C=C3C(C)=C(C#N)C4=C/3C(C)=C(C#N)C(N)=N4)O2)C=C(C(O)=O)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 442.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yao D, Zhang J, Wang J, Pan D, He Z. Discovery of novel ATAD2 bromodomain inhibitors that trigger apoptosis and autophagy in breast cells by structure- based virtual screening. J Enzyme Inhib Med Chem. 2020 Dec;35(1):713-725. doi: 10.1080/14756366.2020.1740924. PMID: 32174193; PMCID: PMC7144325. 2: Ribeiro Filho HV, Bernardi Videira N, Bridi AV, Tittanegro TH, Helena Batista FA, de Carvalho Pereira JG, de Oliveira PSL, Bajgelman MC, Le Maire A, Figueira ACM. Screening for PPAR Non-Agonist Ligands Followed by Characterization of a Hit, AM-879, with Additional No-Adipogenic and cdk5-Mediated Phosphorylation Inhibition Properties. Front Endocrinol (Lausanne). 2018 Feb 1;9:11. doi: 10.3389/fendo.2018.00011. PMID: 29449830; PMCID: PMC5799700.