LY2019-005 | CAS#unknown | LRRK2 kinase inhibitor

MedKoo Cat#: 465788 | Name: LY2019-005

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY2019-005 is a novel LRRK2 kinase inhibitor against the wild-type and G2019S mutant LRRK2 kinase being 424.40 ± 1.31 nM, 378.80 ± 1.20 nM, respectively

Chemical Structure

LY2019-005

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465788

Name: LY2019-005

CAS#: unknown

Chemical Formula: C22H18F3N7

Exact Mass: 437.1576

Molecular Weight: 437.43

Elemental Analysis: C, 60.41; H, 4.15; F, 13.03; N, 22.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

LY2019-005; LY2019005; LY2019 005;

IUPAC/Chemical Name

(Z)-N2-methyl-6-(2-(naphthalen-1-ylmethylene)hydrazinyl)-N4-(3-(trifluoromethyl)phenyl)-1,3,5-triazine-2,4-diamine

InChi Key

QYLLDAJXAXGQDC-WKIKZPBSSA-N

InChi Code

InChI=1S/C22H18F3N7/c1-26-19-29-20(28-17-10-5-9-16(12-17)22(23,24)25)31-21(30-19)32-27-13-15-8-4-7-14-6-2-3-11-18(14)15/h2-13H,1H3,(H3,26,28,29,30,31,32)/b27-13-

SMILES Code

FC(C1=CC(NC2=NC(N/N=C\C3=C(C=CC=C4)C4=CC=C3)=NC(NC)=N2)=CC=C1)(F)F

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 437.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Tan S, Gong X, Liu H, Yao X. Virtual Screening and Biological Activity Evaluation of New Potent Inhibitors Targeting LRRK2 Kinase Domain. ACS Chem Neurosci. 2021 Sep 1;12(17):3214-3224. doi: 10.1021/acschemneuro.1c00399. Epub 2021 Aug 13. PMID: 34387082.