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MedKoo Cat#: 465786 | Name: DD04107

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DD04107 is a novel inhibitor of α-calcitonin gene-related peptide (α-CGRP) exocytotic release from primary sensory neurons, selectively interacting with Synaptotagmin 1.

Chemical Structure

DD04107
DD04107
CAS#1202877-06-2

Theoretical Analysis

MedKoo Cat#: 465786

Name: DD04107

CAS#: 1202877-06-2

Chemical Formula: C48H88N14O12S

Exact Mass: 1084.6427

Molecular Weight: 1085.38

Elemental Analysis: C, 53.12; H, 8.17; N, 18.07; O, 17.69; S, 2.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
DD04107; DD 04107; DD-04107; Pal-EEMQRR-NH2; Palmitoyl-Glu-Glu-Met-Gln-Arg-Arg-NH2;
IUPAC/Chemical Name
N-(1-Oxohexadecyl)-L-α-glutamyl-L-α-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-L-argininamide
InChi Key
MKMGHNXKCFXFRM-NGTAMTFRSA-N
InChi Code
InChI=1S/C48H88N14O12S/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-20-38(64)57-33(22-25-39(65)66)43(71)61-35(23-26-40(67)68)45(73)62-36(27-30-75-2)46(74)60-34(21-24-37(49)63)44(72)59-32(19-17-29-56-48(53)54)42(70)58-31(41(50)69)18-16-28-55-47(51)52/h31-36H,3-30H2,1-2H3,(H2,49,63)(H2,50,69)(H,57,64)(H,58,70)(H,59,72)(H,60,74)(H,61,71)(H,62,73)(H,65,66)(H,67,68)(H4,51,52,55)(H4,53,54,56)/t31-,32-,33-,34-,35-,36-/m0/s1
SMILES Code
N=C(N)NCCC[C@@H](C(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCSC)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC(CCCCCCCCCCCCCCC)=O)=O)=O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,085.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Butrón D, Zamora-Carreras H, Devesa I, Treviño MA, Abian O, Velázquez-Campoy A, Bonache MÁ, Lagartera L, Martín-Martínez M, González-Rodríguez S, Baamonde A, Fernández-Carvajal A, Ferrer-Montiel A, Jiménez MÁ, González-Muñiz R. DD04107-Derived neuronal exocytosis inhibitor peptides: Evidences for synaptotagmin-1 as a putative target. Bioorg Chem. 2021 Oct;115:105231. doi: 10.1016/j.bioorg.2021.105231. Epub 2021 Jul 31. PMID: 34388485. 2: Lakomá J, Rimondini R, Ferrer Montiel A, Donadio V, Liguori R, Caprini M. Increased expression of Trpv1 in peripheral terminals mediates thermal nociception in Fabry disease mouse model. Mol Pain. 2016 Aug 16;12:1744806916663729. doi: 10.1177/1744806916663729. PMID: 27531673; PMCID: PMC5009828. 3: Devesa I, Ferrándiz-Huertas C, Mathivanan S, Wolf C, Luján R, Changeux JP, Ferrer-Montiel A. αCGRP is essential for algesic exocytotic mobilization of TRPV1 channels in peptidergic nociceptors. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18345-50. doi: 10.1073/pnas.1420252111. Epub 2014 Dec 8. PMID: 25489075; PMCID: PMC4280602. 4: Ponsati B, Carreño C, Curto-Reyes V, Valenzuela B, Duart MJ, Van den Nest W, Cauli O, Beltran B, Fernandez J, Borsini F, Caprioli A, Di Serio S, Veretchy M, Baamonde A, Menendez L, Barros F, de la Pena P, Borges R, Felipo V, Planells- Cases R, Ferrer-Montiel A. An inhibitor of neuronal exocytosis (DD04107) displays long-lasting in vivo activity against chronic inflammatory and neuropathic pain. J Pharmacol Exp Ther. 2012 Jun;341(3):634-45. doi: 10.1124/jpet.111.190678. Epub 2012 Mar 5. PMID: 22393248. 5: Camprubí-Robles M, Planells-Cases R, Ferrer-Montiel A. Differential contribution of SNARE-dependent exocytosis to inflammatory potentiation of TRPV1 in nociceptors. FASEB J. 2009 Nov;23(11):3722-33. doi: 10.1096/fj.09-134346. Epub 2009 Jul 7. PMID: 19584302.