MS-143 is a VHL-recruiting AKT degrader. MS-143 suppressed cell growth more effectively than AZD5363 in multiple cancer cell lines. MS-143 displayed good plasma exposure levels in mice and are suitable for in vivo efficacy studies. Lastly, MS-143 effectively suppressed tumor growth in vivo in a xenograft model without apparent toxicity.
MedKoo Cat#: 465764
Name: MS-143
CAS#: 2376137-41-4
Chemical Formula: C59H81ClN12O6S
Exact Mass: 1120.5811
Molecular Weight: 1121.89
Elemental Analysis: C, 63.17; H, 7.28; Cl, 3.16; N, 14.98; O, 8.56; S, 2.86
The following data is based on the product molecular weight 1,121.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
