MedKoo Cat#: 465756 | Name: KF15372

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KF15372 is an adenosine receptor antagonist.

Chemical Structure

KF15372
KF15372
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465756

Name: KF15372

CAS#: unknown

Chemical Formula: C18H26N4O2

Exact Mass: 330.2056

Molecular Weight: 330.43

Elemental Analysis: C, 65.43; H, 7.93; N, 16.96; O, 9.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
KF15372; K F15372; K-F15372;
IUPAC/Chemical Name
8-(dicyclopropylmethyl)-1,3-dipropyl-3,7-dihydro-1H-purine-2,6-dione
InChi Key
OEPXIQLEKWHAGE-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H26N4O2/c1-3-9-21-16-14(17(23)22(10-4-2)18(21)24)19-15(20-16)13(11-5-6-11)12-7-8-12/h11-13H,3-10H2,1-2H3,(H,19,20)
SMILES Code
O=C1C2=C(N=C(C(C3CC3)C4CC4)N2)N(CCC)C(N1CCC)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 330.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Leung K. [1-methyl-11C]8-Dicyclopropylmethyl-1-methyl-3-propylxanthine. 2006 Feb 10 [updated 2008 Jul 6]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641820. 2: Leung K. 8-Cyclopentyl-3-(3-[18F]fluoropropyl)-1-propylxanthine. 2006 Feb 13 [updated 2006 Jul 8]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641797. 3: Ohmori H, Sato Y, Namiki A. The anticonvulsant action of propofol on epileptiform activity in rat hippocampal slices. Anesth Analg. 2004 Oct;99(4):1095-1101. doi: 10.1213/01.ANE.0000130356.22414.2B. PMID: 15385357. 4: Shimada Y, Ishiwata K, Kiyosawa M, Nariai T, Oda K, Toyama H, Suzuki F, Ono K, Senda M. Mapping adenosine A(1) receptors in the cat brain by positron emission tomography with [(11)C]MPDX. Nucl Med Biol. 2002 Jan;29(1):29-37. doi: 10.1016/s0969-8051(01)00265-7. PMID: 11786273. 5: Hirani E, Gillies J, Karasawa A, Shimada J, Kase H, Opacka-Juffry J, Osman S, Luthra SK, Hume SP, Brooks DJ. Evaluation of [4-O-methyl-(11)C]KW-6002 as a potential PET ligand for mapping central adenosine A(2A) receptors in rats. Synapse. 2001 Dec 1;42(3):164-76. doi: 10.1002/syn.1110. PMID: 11746713. 6: Ishiwata K, Shimada J, Wang WF, Harakawa H, Ishii S, Kiyosawa M, Suzuki F, Senda M. Evaluation of iodinated and brominated [11C]styrylxanthine derivatives as in vivo radioligands mapping adenosine A2A receptor in the central nervous system. Ann Nucl Med. 2000 Aug;14(4):247-53. doi: 10.1007/BF02988206. PMID: 11023024. 7: Wakabayashi S, Nariai T, Ishiwata K, Nagaoka T, Hirakawa K, Oda K, Sakiyama Y, Shumiya S, Toyama H, Suzuki F, Senda M. A PET study of adenosine A1 receptor in anesthetized monkey brain. Nucl Med Biol. 2000 May;27(4):401-6. doi: 10.1016/s0969-8051(00)00089-5. PMID: 10938476. 8: Ishiwata K, Noguchi J, Wakabayashi S, Shimada J, Ogi N, Nariai T, Tanaka A, Endo K, Suzuki F, Senda M. 11C-labeled KF18446: a potential central nervous system adenosine A2a receptor ligand. J Nucl Med. 2000 Feb;41(2):345-54. PMID: 10688121. 9: Noguchi J, Ishiwata K, Wakabayashi S, Nariai T, Shumiya S, Ishii S, Toyama H, Endo K, Suzuki F, Senda M. Evaluation of carbon-11-labeled KF17837: a potential CNS adenosine A2a receptor ligand. J Nucl Med. 1998 Mar;39(3):498-503. PMID: 9529299. 10: Ishiwata K, Sakiyama Y, Sakiyama T, Shimada J, Toyama H, Oda K, Suzuki F, Senda M. Myocardial adenosine A2a receptor imaging of rabbit by PET with [11C]KF17837. Ann Nucl Med. 1997 Aug;11(3):219-25. doi: 10.1007/BF03164767. PMID: 9310171. 11: Noguchi J, Ishiwata K, Furuta R, Simada J, Kiyosawa M, Ishii S, Endo K, Suzuki F, Senda M. Evaluation of carbon-11 labeled KF15372 and its ethyl and methyl derivatives as a potential CNS adenosine A1 receptor ligand. Nucl Med Biol. 1997 Jan;24(1):53-9. doi: 10.1016/s0969-8051(96)00161-8. PMID: 9080475. 12: Furuta R, Ishiwata K, Kiyosawa M, Ishii S, Saito N, Shimada J, Endo K, Suzuki F, Senda M. Carbon-11-labeled KF15372: a potential central nervous system adenosine A1 receptor ligand. J Nucl Med. 1996 Jul;37(7):1203-7. PMID: 8965199. 13: Kurokawa M, Shiozaki S, Nonaka H, Kase H, Nakamura J, Kuwana Y. In vivo regulation of acetylcholine release via adenosine A1 receptor in rat cerebral cortex. Neurosci Lett. 1996 May 17;209(3):181-4. doi: 10.1016/0304-3940(96)12632-x. PMID: 8736640. 14: Ishiwata K, Furuta R, Shimada J, Ishii S, Endo K, Suzuki F, Senda M. Synthesis and preliminary evaluation of [11C]KF15372, a selective adenosine A1 antagonist. Appl Radiat Isot. 1995 Oct;46(10):1009-13. doi: 10.1016/0969-8043(95)00197-l. PMID: 7496369. 15: Pauwels RA, Joos GF. Characterization of the adenosine receptors in the airways. Arch Int Pharmacodyn Ther. 1995 Jan-Feb;329(1):151-60. PMID: 7639616. 16: Suzuki F, Shimada J, Shiozaki S, Ichikawa S, Ishii A, Nakamura J, Nonaka H, Kobayashi H, Fuse E. Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. J Med Chem. 1993 Aug 20;36(17):2508-18. doi: 10.1021/jm00069a009. PMID: 8355252. 17: Karasawa A, Rochester JA, Lefer AM. Effects of adenosine, an adenosine-A1 antagonist, and their combination in splanchnic occlusion shock in rats. Circ Shock. 1992 Feb;36(2):154-61. PMID: 1582007. 18: Shimada J, Suzuki F, Nonaka H, Karasawa A, Mizumoto H, Ohno T, Kubo K, Ishii A. 8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities. J Med Chem. 1991 Jan;34(1):466-9. doi: 10.1021/jm00105a072. PMID: 1992150.