DATPT is a 12WLVSKF17 peptide-mimetic small molecule has been identified. DATPT can block the SNX9−p47phox interaction in the endosome and suppress reactive oxygen species and inflammatory cytokine production; it demonstrated significant therapeutic effects in a mouse model of cecal ligation and puncture-induced sepsis. DATPT has considerably improved potency, with an IC50 500-fold (in vitro) or 2000-fold (in vivo) lower than that of the 12WLVSKF17 peptide. Furthermore, DATPT shows potent antibacterial activities by reduction in ATP production and leakage of intracellular ATP out of bacteria.
MedKoo Cat#: 465742
Name: DATPT
CAS#: unknown
Chemical Formula: C24H39ClN6O3
Exact Mass: 494.2772
Molecular Weight: 495.07
Elemental Analysis: C, 58.23; H, 7.94; Cl, 7.16; N, 16.98; O, 9.70
The following data is based on the product molecular weight 495.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
