PLX7922, a RAF inhibitor, can bind with BRAFV600E. In vitro, PLX7922 inhibits pERK in BRAFV600E cell lines, and activates pERK in mutant NRAS cell lines.
MedKoo Cat#: 465737
Name: PLX7922
CAS#: 1638772-61-8
Chemical Formula: C20H25FN6O2S2
Exact Mass: 464.1464
Molecular Weight: 464.58
Elemental Analysis: C, 51.71; H, 5.42; F, 4.09; N, 18.09; O, 6.89; S, 13.80
The following data is based on the product molecular weight 464.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
