JYQ-42 is a potent allosteric inhibitor of SIRT6. JYQ-42, the most efficient SIRT6-specific allosteric noncompetitive inhibitor, selectively targets SIRT6 and effectively inhibits the deacetylation activity of SIRT6 through several critical residue interactions. The IC50 value of JYQ-42 is 2.33 ± 0.17 μM.
MedKoo Cat#: 465721
Name: JYQ-42
CAS#: 2838025-41-3
Chemical Formula: C13H8ClF3N8O2
Exact Mass: 400.0411
Molecular Weight: 400.71
Elemental Analysis: C, 38.97; H, 2.01; Cl, 8.85; F, 14.22; N, 27.96; O, 7.99
The following data is based on the product molecular weight 400.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
